This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $382,500.00 to study the role of the protein TXLNA in innate immune responses to cytosolic DNA. The research aims to determine how TXLNA regulates the STING-mediated activation of TBK1, a key signaling pathway involved in the production of type I interferons in response to cytosolic DNA. The project will employ a knockout mouse model and molecular biology techniques to elucidate the regulatory mechanisms governing this pathway, with the goal of informing the development of therapeutic strategies for infectious diseases and autoimmune disorders. The award period runs from June 20, 2025 to May 31, 2030 and is being conducted by Tulane University, a private non-profit research institution.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $382.5k | 6/20/25 |