Project Grant R01AI188698
- The University of South Florida (USF) received a $480,522 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant supports research to investigate the regulation and role of the secreted proteases of the bacterium Staphylococcus aureus, a major cause of infectious disease. The research aims to elucidate how these enzymes mediate S. aureus pathogenesis and virulence, with...
- This $236,100 Project Grant awarded on January 10, 2025 by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to characterize two uncharacterized small regulatory RNAs (sRNAs), RsaX20 and S1077, in Staphylococcus aureus (S. aureus). The research aims to elucidate the mechanisms controlling expression of these sRNAs, assess heterogeneity in expression at the single-cell level, and determine their roles in regulating...
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $390,000 to support research on the molecular basis of Staphylococcus aureus SPLB manipulation of the host. The research aims to: 1) identify host protein targets of S. aureus SPLB, 2) elucidate how SPLB-target interactions induce conformational changes, and 3) determine how N-terminal cleavage activates the...
- This federal Project Grant award of $208,332 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to advance understanding of how Staphylococcus aureus, a leading global pathogen, causes spine infections in humans. The award to New York University School of Medicine will support research to evaluate the contributions of specific S. aureus virulence factors in enabling the pathogen to evade the human immune system and cause...
- This Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $188,916 award supports research by Brigham & Women's Hospital Inc. to investigate how the bacterium Staphylococcus aureus, a leading infectious cause of death globally, is able to evade the immune system and persist during bloodstream infections. The research aims to determine how noncytotoxic (non-toxic)...
- The University of Wisconsin - Madison received a $560,178 Project Grant from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to investigate the role of Staphylococcus aureus prophages as molecular regulatory switches that control the production of the virulent B-toxin. The goal is to elucidate the temporal dynamics of the FSA3 prophage in mediating "active lysogeny" and B-toxin expression in S. aureus lineages under...
- This $2,976,652 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), aims to explore how polyamines impact methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes, two dangerous human skin pathogens. The research will investigate how these pathogens develop resistance to polyamines, which are highly toxic to them, and seek to develop novel synthetic...
- This $420,553 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to develop a single-cell technique that will measure the translation rate and transcriptome of thousands of individual bacterial cells, with a focus on understanding antibiotic tolerance in Staphylococcus aureus during chronic infections. The research will explore the heterogeneity in...
- This $226,253 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand how the host protein ADAM10 modulates the interactions between neutrophils and the endothelium during Staphylococcus aureus infection. The project aims to generate a spatiotemporal analysis of these key cellular and molecular interactions in the early stages of infection, leveraging...
- This Project Grant award of $115,123 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to reveal strategies for eradicating antibiotic-tolerant Staphylococcus aureus persister cells. The research aims to identify the host cells harboring intracellular S. aureus reservoirs and characterize the host and bacterial transcriptomes using single-cell approaches. Additionally, the project...
The University of South Florida (USF) received a $470,953 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant funding supports research to determine the role and regulation of the regulatory RNA SSR42 in virulence factor regulation in Staphylococcus aureus (S. aureus). The research aims to characterize how SSR42 impacts S. aureus virulence, including effects on hemolytic activity, cytolytic activity, proteolytic capacity, and survival/dissemination in murine models of sepsis and pneumonia. This work seeks to address a major knowledge gap in understanding this important, yet understudied, component of the S. aureus regulatory machinery. The award period runs from August 1, 2025 through July 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $471.0k | 8/1/25 |