Project Grant R21AI187793
- This Project Grant award of $115,123 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to reveal strategies for eradicating antibiotic-tolerant Staphylococcus aureus persister cells. The research aims to identify the host cells harboring intracellular S. aureus reservoirs and characterize the host and bacterial transcriptomes using single-cell approaches. Additionally, the project...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $490,093 Project Grant to the University of Maryland, College Park on April 10, 2025. The funding supports the development of a rapid, inexpensive microfluidic technology to isolate bacteria directly from whole blood, identify pathogens, and evaluate their antibiotic response within 75 minutes. This will enable clinicians to move...
- This $481,250 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855). The grant will fund the development of new antimicrobial small molecule compounds that recruit the immune system to target bacteria. Key activities include the biochemical, biophysical, and cell biology characterization of these chimeric molecules formed by joining bacterial binding agents with...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a Project Grant of $109,476 under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to the University of Wisconsin - Madison. The grant, titled "Understanding the Molecular Rules of a Bacterial Multidrug Efflux Transporter", aims to measure the function of 7,760 single mutations in the NorA multidrug efflux pump to better understand the mechanisms of antimicrobial resistance. The...
- This $475,036 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund research to explore synergistic combinations of aminoglycoside antibiotics against multidrug-resistant (MDR) gram-negative bacteria. The project aims to: 1) examine dual-aminoglycoside combinations against MDR pathogens like Enterobacter cloacae, E. coli, and Klebsiella pneumoniae, 2) solve the structural details of how multiple...
- This $2,976,652 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), aims to explore how polyamines impact methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pyogenes, two dangerous human skin pathogens. The research will investigate how these pathogens develop resistance to polyamines, which are highly toxic to them, and seek to develop novel synthetic...
- This Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The $188,916 award supports research by Brigham & Women's Hospital Inc. to investigate how the bacterium Staphylococcus aureus, a leading infectious cause of death globally, is able to evade the immune system and persist during bloodstream infections. The research aims to determine how noncytotoxic (non-toxic)...
- The University of South Florida (USF) received a $470,953 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant funding supports research to determine the role and regulation of the regulatory RNA SSR42 in virulence factor regulation in Staphylococcus aureus (S. aureus). The research aims to characterize how SSR42 impacts S. aureus virulence, including effects on hemolytic...
- This federal Project Grant award, totaling $404,108, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to identify the key genetic and signaling pathways that enable Mycobacterium tuberculosis (MTB) to form antibiotic persister cells, which can survive prolonged exposure to lethal antibiotics. The research aims to apply genetic and proteomic approaches to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $142,492 Project Grant under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855) to The Washington University in Missouri. The grant, titled "High Throughput Identification of Bacteriophages and Their Hosts with Single-Cell Transcriptomics," aims to establish an innovative, high-throughput phage-host pairing tool for rapidly screening complex, naturally occurring microbial...
This $420,553 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant aims to develop a single-cell technique that will measure the translation rate and transcriptome of thousands of individual bacterial cells, with a focus on understanding antibiotic tolerance in Staphylococcus aureus during chronic infections. The research will explore the heterogeneity in translational and transcriptomic activity of S. aureus cells and determine if an increasing percentage of the population enters a low-activity state over time in the presence of antibiotics. This 2-year project is scheduled for completion by July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $420.6k | 8/8/25 |