Project Grant K08AI177741

Award Date 6/16/25
Completion Date 5/31/30
Dollars Obligated $208K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
New York, NY 10016, USA
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  1. Clarifying the role of S. aureus surface proteins in promoting spine infection, and investigating how the immune evasion properties of these proteins and the CHIPS virulence factor contribute to spinal cord injury.

  2. Determining the mechanism by which CHIPS interferes with the C5a-C5aR1 axis to disrupt neutrophil function and enable S. aureus to evade host immune killing.

  3. Exploring vaccination approaches targeting the CHIPS virulence factor to prevent the debilitating impact of S. aureus spine infections.

The research will leverage a novel humanized mouse model developed by the awardee, New York University School of Medicine, to better understand how S. aureus adapts to the human host and causes this severe disease in patients.

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