This Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research at the University of North Carolina at Chapel Hill to define the interplay between stochastic and regulatory mechanisms underlying the heterogeneous expression of flagella and toxins in Clostridioides difficile. The $521,030 award, effective from November 18, 2024 to October 31, 2029, will support molecular genetics, single-cell analyses, and animal model studies to investigate how C. difficile controls production of key virulence factors and the impact on bacterial fitness during intestinal infection. The research aims to provide mechanistic insights into how C. difficile, a leading cause of antibiotic-associated infections, adapts to the intestinal environment and generates phenotypic heterogeneity to ensure survival.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $521.0k | 11/18/24 |