Project Grant R01AI187618
- This Project Grant, valued at $868,776.00 and awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), supports research to characterize a novel post-transcriptional regulator in the opportunistic pathogen Pseudomonas aeruginosa. The key objectives are to identify the direct regulatory targets of this regulator, called PhAF, under standard laboratory conditions and in clinically relevant...
- This $236,100 Project Grant awarded on January 10, 2025 by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to characterize two uncharacterized small regulatory RNAs (sRNAs), RsaX20 and S1077, in Staphylococcus aureus (S. aureus). The research aims to elucidate the mechanisms controlling expression of these sRNAs, assess heterogeneity in expression at the single-cell level, and determine their roles in regulating...
- This $422,355 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports mechanistic studies of the signaling histidine kinase GacS from the nosocomial pathogen Pseudomonas aeruginosa. The research aims to experimentally validate conformational changes in GacS predicted by molecular dynamics simulations and directly measure the impact of ligand binding on the shape and flexibility of...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $151,040 Project Grant under the Allergy and Infectious Diseases Research Program (CFDA 93.855) to The Children's Hospital Corporation (doing business as Boston Children's Hospital) for the project "Investigating the Regulatory Impact of the Small Regulatory RNA BECO on Essential Virulence Factors in Pseudomonas Aeruginosa". This grant aims to investigate how the small regulatory RNA BECO regulates the...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $779,915 Project Grant to the Scripps Research Institute to investigate the chromatin remodeling functions of polyphosphate condensates in the bacterial pathogen Pseudomonas aeruginosa. The grant, awarded under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), will support research to understand how polyphosphate, a polymer produced by bacteria in response to stress, interacts with the...
- This $849,713 Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) supports research to elucidate RNA-RNA interaction networks during interbacterial interactions involving the bacterium Pseudomonas aeruginosa. The research team at Boston Children's Hospital seeks to define the small RNA (sRNA) interaction network in P. aeruginosa and decode the regulatory roles played by sRNAs during its interactions with other bacteria. The project will...
- This $430,760 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), which administers the Allergy and Infectious Diseases Research program (CFDA 93.855), to the University of Pittsburgh. The grant supports research to train neutrophils, a type of white blood cell, to defend against a lethal bacterial infection of the lung caused by Pseudomonas aeruginosa. The key objectives are to establish a strategy to improve the host's immune defense against this...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $105,076 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Trustees of Dartmouth College to study the dual function of the T6SS immunity protein TSIT in regulating Pseudomonas aeruginosa biofilm growth. The research aims to test the hypothesis that TSIT acts as a transcription factor, in addition to its role as a T6SS immunity protein, to regulate biofilm formation - a key...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $439,896 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to William Marsh Rice University in Houston, Texas. The grant supports research to develop R pyocins, which are phage tail-like protein complexes, as a novel approach to target multidrug-resistant Pseudomonas aeruginosa, a serious bacterial threat. The research aims to leverage the strain-specific killing ability of R...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $453,750 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), for research on Pseudomonas aeruginosa infections and neutrophil swarming behavior. The funding will support a 2-year project to develop an ex vivo model to study how neutrophils coordinate to surround and neutralize large bacterial...
This Project Grant award of $775,184 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to elucidate the function of two small RNA genes (SicX and PA3237) that are highly expressed in human chronic Pseudomonas aeruginosa infections. The research will: (i) define the mechanism by which SicX controls its target genes; (ii) elucidate the mechanisms controlling SicX-mediated dissemination in a murine surgical wound model; and (iii) identify the targets of the PA3237 small RNA, focusing on its role in promoting antimicrobial tolerance. This 5-year project conducted by Georgia Tech Research Corp. seeks to improve understanding of P. aeruginosa physiology in polymicrobial wound infections, potentially uncovering new diagnostic and therapeutic targets.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $775.2k | 7/25/25 |