This federal Project Grant award of $576,501 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research by the University of Texas Medical Branch at Galveston (UTMB) on the role of the Lassa virus (LASV) NP exoribonuclease in controlling viral RNA fidelity and replication. The research aims to leverage animal models to investigate the impact of NP exonuclease function on LASV RNA mutation, production of non-standard viral RNAs, and virus pathogenicity. It will also examine potential compensatory mutations in the LASV RNA-dependent RNA polymerase that may improve RNA synthesis and fidelity. Additionally, biochemical studies will explore the mechanism by which the NP exonuclease reduces RNA substitution. The project period runs from August 1, 2025 to July 31, 2030 and seeks to advance the understanding of arenavirus biology and identify potential new targets for Lassa fever treatments and vaccines.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $576.5k | 7/23/25 |