This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $798,400.00 to the University of Texas Medical Branch at Galveston to investigate a circular RNA vaccine platform for the Andes virus (ANDV), a hantavirus that causes severe disease. The research aims to examine the ability of the circular RNA vaccine to induce potent and durable adaptive immune responses, including germinal center responses, long-lived plasma cells, memory B cells, and T cell responses, in comparison to a linear mRNA vaccine platform. The research will employ molecular, virological, and immunological expertise, as well as access to biocontainment facilities, to accomplish these objectives. The proposed work has the potential to facilitate the development of an innovative circular RNA-based vaccine against ANDV that may serve as a prototype for other bunyaviruses.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $798.4k | 5/7/25 |