Project Grant R01AI185760

Award Date 8/1/25
Completion Date 7/31/29
Dollars Obligated $2.9M
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Florida, USA
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The federal Project Grant award R01AI178776 was issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) program. The $1,541,024 grant awarded to the University of Notre Dame DU Lac aims to elucidate the spore germination pathway of Clostridioides difficile and develop pharmacological interventions to inhibit spore germination, which is a key driver of recurrent C. difficile infections (CDI). The research project...
This $780,162 Project Grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases will fund research at Old Dominion University from August 2022 through July 2026 exploring the role of nutrient and stress sensing in regulating Clostridioides difficile physiology and behavior within the host. The research aims to determine how the stringent response regulates disease-relevant bacterial processes and characterize enzymes that mediate alarmone metabolism...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $136,104 to Tufts University School of Medicine to conduct research on the impact of Clostridioides difficile's spatial distribution and toxin gene expression on disease severity. The researchers aim to use fluorescent reporter strains to visualize C. difficile cells and their toxin gene expression during murine...
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This $894,552 project grant from the National Institutes of Health's National Institute of Allergy and Infectious Diseases Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research at the University of Nevada, Las Vegas to probe the effect of a high-fat/high-protein diet on Clostridioides difficile infection. Specifically, the researchers will examine how such a diet impacts inflammation, intestinal permeability, and the gut microbiome before and after antibiotic...
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