Project Grant R01AI184990
- This federal Project Grant award of $1,024,897.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund research at the University of Pennsylvania to dissect the role of innate immune cell responses, particularly inflammatory monocytes and neutrophils, in controlling intestinal and systemic Yersinia infection. The research aims to define how a monocyte-driven TNF-IL-1 signaling circuit mediates control of Yersinia...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $531,245 to Yale University to conduct research on the structure and function of the Salmonella type III secretion sorting platform. Through a multidisciplinary approach, the research aims to investigate the mechanism by which the sorting platform selects and sorts client proteins essential for the pathogenicity of...
- This federal Project Grant award of $195,213 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research by the University of California, Davis to investigate the mechanisms by which the gut microbiota, specifically short-chain fatty acids, can inhibit the growth of the enteric pathogen Yersinia enterocolitica. The research aims to elucidate the molecular mechanisms underlying Y. enterocolitica's sensitivity and...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), provides $256,995.00 to Tufts University School of Medicine to conduct research on how intravacuolar pathogens like Legionella pneumophila establish infection within host cells. The research aims to quantitatively link pathogen traits, such as fitness, to host cell mutations using optical sequencing techniques....
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,262,539 to Yale University to elucidate the molecular mechanisms underlying the assembly of the mycobacterial cell envelope, a critical barrier to antibiotics. The research aims to investigate the synthesis and transport of mycolic acids, the function of an essential efflux pump, and the regulation of mycomembrane biosynthesis. These studies...
- This federal Project Grant award of $828,820 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to Weill Medical College of Cornell University aims to investigate the molecular mechanisms by which the commensal bacterium Enterococcus faecalis transitions from a harmless gut resident to a pathogen that can breach the intestinal barrier and cause life-threatening systemic infections. The key objectives are to: 1) Define how E....
- This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), is providing $125,901 to Harvard Medical School to investigate the mechanism by which certain outer membrane proteins in mycobacterial species are transported and assembled. The goal is to understand this process, which is critical for the integrity of the bacterial cell envelope and could lead to new antimicrobial...
- This $147,656 federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to understand the role of transmembrane proteins in the cell division process of the malaria parasite Plasmodium falciparum. The award, effective January 22, 2025 through October 31, 2027, will enable the integration of biochemical and super-resolution microscopy approaches to decipher...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $204,347 Project Grant (CFDA 93.855 - Allergy and Infectious Diseases Research) to the University of Vermont & State Agricultural College to study the intracellular colonization strategies of Salmonella enterica serovar Typhimurium within human intestinal epithelial cells and macrophages. The research aims to characterize bacterial and host transcripts during Salmonella infection, distinguish between cytosolic and...
- This $453,750 Project Grant was awarded on August 1, 2025 by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports research to study how certain bacteriophages (phages) can evade the antiviral defense mechanisms of bacteria, including deadly pathogens like Vibrio cholerae. The research aims to determine the counter-defense mechanisms used by a specific phage protein to antagonize the...
This Project Grant award of $3,178,626 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to investigate the interactions between the enteric pathogen Yersinia pseudotuberculosis and microfold (M) cells in the gastrointestinal epithelium. The award to Tufts University School of Medicine, with a performance period from Aug 2025 to Jul 2029, will utilize a differentiated human ileum organoid model to study how the pathogen exploits M cells to gain access to the lymph system and deeper tissues. Key objectives include elucidating the mechanisms by which the pathogen's type 3 secretion system affects its interactions with and delivery across M cells. The findings are expected to advance scientific understanding of pathogen-host cell dynamics and inform the development of interventions targeting enteric infections.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.2m | 8/26/25 |