This $870,800 federal Project Grant award was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The primary purpose of this 2-year award, with a completion date of March 31, 2026, is to conduct innovative research to discriminate pathogenic from benign genetic variants of the DDX41 gene, which has been implicated in predisposing individuals to myelodysplastic syndrome (MDS) and acute myeloid...
This federal Project Grant award of $799,017 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to define the function and distribution of natural killer (NK) cells in tissues from SIV-infected, ART-treated rhesus macaques after IL-21 administration. The research aims to evaluate if the levels of terminally-differentiated NK cells induced by IL-21 can be durably prolonged after treatment interruption, and...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (under CFDA 93.855 - Allergy and Infectious Diseases Research) provides $220,695 to the University of California, Los Angeles (UCLA) from June 15, 2024 to March 31, 2026. The grant supports research to investigate the role of the transcription factor MEF2C in regulating natural killer (NK) cell metabolism and antiviral effector function. Specifically, the project aims to test whether MEF2C is...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $682,879 to The Medical College of Wisconsin, Inc. to conduct research on how human cytomegalovirus (HCMV) infection impacts the development of human neural tissues. The research aims to: 1) Define the transcriptional and cellular disruptions to developing human neural cells caused by HCMV infection, 2) Determine the impact of specific viral...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $256,500.00 to the Fred Hutchinson Cancer Center (doing business as the Seattle Cancer Care Alliance) to conduct research on the regulation of mucosal immunity and the coordination of the NK cell response during viral infections. The research aims to improve understanding of how regulatory T cells modulate NK cell activation and function in...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $114,722 to Sloan-Kettering Institute For Cancer Research to investigate the molecular basis of the context-dependent role of the STAT3 transcription factor in natural killer (NK) cells during viral infections. The research aims to 1) determine how different upstream signals alter STAT3's impact on NK cell...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $217,350 to Duke University to conduct research on harnessing CD89+ natural killer (NK) cells for novel therapeutic interventions against HIV/SIV. The project aims to:
Characterize the role(s) and functional regulation of CD89+ NK cells in the mucosae in normal and SIV/SHIV-infected macaques.
Investigate the role of autologous CD89+...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $390,000 to The Medical College of Wisconsin, Inc. over a 5-year period from 2025 to 2029. The objective of this research project is to improve the foundational knowledge of immune cell biology in vivo, focusing on the ontogeny, kinetics, and function of tissue-resident macrophages. The researchers will utilize a novel small and...
This federal Project Grant award, with ID R01AI179712, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855).
The approximately $857,346 award will fund research by the Fred Hutchinson Cancer Center (doing business as Seattle Cancer Care Alliance) to investigate how activating and inhibitory signals in the form of cytokines and metabolites present in healthy human tissues regulate the effector...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $219,792 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Wisconsin - Madison. The grant, titled "Statistical Methods for TCR-Sequencing Experiments", will fund the development of statistical methods to analyze high-throughput T-cell receptor (TCR) sequencing data. This research aims to ensure that critical information from TCR profiling experiments...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $729,047 to The Medical College of Wisconsin, Inc. to conduct research on the GATA2-TGF-beta-TAL1 pathway and its role in natural killer (NK) cell development.
The research aims to uncover a novel transcriptional network involving GATA2, TGF-beta, and TAL1 that is essential for human NK cell development and function. The project will employ various genomic and molecular techniques, including single-cell RNA sequencing, mRNA/siRNA delivery, and conditional gene knockout models, to better understand this pathway and its implications for diseases like MonoMAC syndrome that involve GATA2 mutations. The findings are expected to advance the understanding of transcriptional regulation in NK cell development, with potential applications for improving treatments for immune system disorders. The award period runs from December 2024 through November 2029.