Project Grant R01AI182321

Award Date 11/12/24
Completion Date 10/31/29
Dollars Obligated $770K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Minneapolis, MN 55455, USA
Similar Awards
This $1,736,846 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to gain new insights into the assembly and maturation of deltaretroviruses, a class of complex retroviruses associated with lymphoid leukemias in humans and cattle. The research team at the University of Minnesota will apply advanced imaging techniques such as cryo-electron microscopy, super-resolution...
This federal Project Grant award from the National Institutes of Health (NIH), under the Trans-NIH Research Support (CFDA 93.310) program, provides $1,367,863 to Emory University to conduct biophysical research on herpesvirus capsid assembly and genome packaging. The goal is to develop new methodologies to monitor these essential viral processes in real-time, which could lead to a more complete understanding of herpesviral replication and the development of improved preventative and...
This $659,949 Project Grant award from the National Institute of General Medical Sciences (NIGMS), funded under CFDA 93.859 Biomedical Research and Research Training program, supports research at the University of Connecticut to investigate the assembly and host interactions of bacteriophage P22, a model double-stranded DNA virus. The key goals are to 1) reveal how the phage scaffolding protein interacts with capsid proteins to control proper assembly, 2) understand the scaffolding protein...
This $453,900 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant is funding research to develop a genome editing platform using broadly functioning phage recombinases, which can be used to genetically manipulate a wide range of bacterial species, including clinically relevant pathogens. The goal is to enable direct investigation of the genetic elements driving bacterial...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will provide $729,006 over a period of 5 years starting January 14, 2025 to study how the adenovirus manipulates host RNA binding proteins to support viral infection. The research will employ advanced proteomics and imaging techniques to define the mechanisms by which the adenovirus alters RNA-protein complexes and evades...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $370,190 to San Diego State University Foundation to conduct direct measurements of RNA virus nucleocapsid self-assembly and disassembly. The research aims to uncover potentially universal mechanisms of these essential viral processes across multiple RNA-packaging virus types, with a focus on the role of RNA sequence and structure....
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $153,512 to The Washington University in St. Louis to conduct research on how bacteria's anti-viral defense system, known as the DARTG system, senses and responds to bacteriophage (viral) infection. The goal is to elucidate the mechanisms by which the DARG1 protein, which is part of the DARTG anti-viral system, can...
This Project Grant award of $375,430 from the National Institutes of Health's Biomedical Research and Research Training program (CFDA 93.859) supports research to understand how viral pathogens hijack cellular DNA replication and repair machinery for their own benefit. The goal is to develop novel tools and methodologies to interrogate how viruses modulate host genome stability signals, localize to cellular DNA break sites, and tether themselves to these sites for long-term persistence. The...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $125,160 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to The Ohio State University to characterize a novel bacterial immune system with unknown mechanisms. The grant will fund research to define the structure and assembly mechanisms of a two-component system, named A and B, that forms a large complex for anti-phage defense. The project will utilize cryogenic electron microscopy...
This $303,076 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to determine the molecular, cellular, and evolutionary mechanisms by which viral pathogens evade or co-opt host innate immune defensin peptides to enhance infectivity. The studies will use a library of chimeric defensin peptides to investigate the structural and biochemical properties...

This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), provides $769,831 to the Regents of the University of Minnesota to study the mechanism of DNA packaging for double-stranded DNA viruses. The research will focus on the Bacillus subtilis bacteriophage F29, using an integrated genetic, biochemical, single-molecule, and structural approach to characterize protein conformational changes and movement in the viral packaging motor during DNA encapsidation. The insights gained will serve as a model for understanding the packaging mechanisms in animal viruses like herpesviruses and adenoviruses, potentially aiding in the development of new antiviral therapies. The award period is from November 12, 2024 to October 31, 2029.

Generated 7/1/25, 3:03 AM