Project Grant R01AI181999

Award Date 11/14/24
Completion Date 10/31/29
Dollars Obligated $659K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Philadelphia, PA 19104, USA
Similar Awards
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $831,755 over 5 years to New York University (NYU) to conduct research on the role of lung-resident macrophage subsets in regulating type 2 immune responses and trained immunity. The research aims to elucidate the distinct functions of different macrophage populations, particularly nerve- and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $936,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Colorado-Denver. The 5-year grant, which commenced on August 12, 2024, will support research to elucidate the regulation and function of tissue-resident eosinophils in allergic microenvironments. The project aims to 1) target cell cycle machinery to manipulate eosinophil specialization, 2) delineate pre-...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $207,500 to the University of Southern California to study the role of the MIF/CD74 pathway in group 2 innate lymphoid cells (ILC2) and its impact on airway hyperreactivity and asthma. The key objectives of this 2-year research project are to: 1) Assess the expression patterns of CD74 in the lungs and measure...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $2,205,213 Project Grant under the Allergy and Infectious Diseases Research (CFDA 93.855) program to the Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center. The grant, titled "Deciphering Immunopathogenesis of Mucormycosis to Advance Risk Stratification, Diagnosis and Management of the Disease", aims to improve understanding of the immune response and pathogenesis of mucormycosis, a...
This $2,654,646 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under CFDA 93.855 Allergy and Infectious Diseases Research supports a multi-year program to better understand the unique characteristics of the human immune response in early life. The program aims to uncover genetic and developmental determinants of pediatric immunity, examine how immune parameters evolve over childhood, and elucidate how baseline immune states predict responses to...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $534,000 to The Children's Hospital of Philadelphia (CHOP) over a period of approximately 2 years starting November 2024. The goal of the project is to study how the location of antigens and the density and half-life of peptide:MHC class II complexes on antigen-presenting cells impact the differentiation and...
This federal Project Grant award of $586,250 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will support research at the University of Massachusetts Medical School (UMass Medical) to investigate the generation and regulation of TFH13 cells that drive pathogenic IgE in allergic conditions. The overarching goal is to elucidate the pathways leading to TFH13 cell differentiation, which play a critical...
This Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to determine how germinal center (GC) responses are controlled in health and how governance loss promotes immune deficiencies and autoimmune diseases. The key objectives are to establish the lineage and functional differences between induced T follicular regulatory (iTFR) and natural TFR (nTFR) cells, and assess...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,426 to The Children's Hospital of Philadelphia (CHOP) to conduct research on chronic STAT3 signaling and its impact on CD8 T cell dysfunction. The key objectives are to investigate the role of the CD39/adenosine axis in impairing CD8 T cell function in the context of STAT3 gain-of-function (GOF) disease, and to...
This Project Grant award of $194,740 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to characterize the development of lung-resident, self-antigen-specific regulatory T cells (Tregs) following acute lung injury. The goal is to understand how these "experienced" Tregs can promote tolerance and prevent future autoimmunity. The principal investigator, Dr. Daniel Shin at...

This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $659,341 to The Children's Hospital of Philadelphia to conduct research on how the protein CUL5 regulates a specific type of immune cell, called ILC2 cells, during helminth (parasitic worm) infections in the lung. The 5-year project aims to: 1) determine how CUL5 expression in IL-18R+ ILC2 cells impacts the clearance of helminth larvae from the lung and recruitment of larvae-killing neutrophils; 2) elucidate how CUL5 regulates signaling downstream of the IL-18 receptor in ILC2 cells; and 3) investigate whether CUL5 regulation of ILC2 function is limited to the lung or also occurs at other mucosal barrier surfaces. This research seeks to enhance understanding of functionally distinct ILC2 subsets and their role in type 2 immune responses, which could inform the development of therapies for treating helminth infections and allergic diseases.

Generated 8/5/25, 6:21 AM