Project Grant R01AI179974

Award Date 7/11/24
Completion Date 5/31/29
Dollars Obligated $3.1M
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Rochester, MN 55905, USA
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This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $3,089,194 to the Mayo Clinic to develop engineered mesenchymal stromal cells (MSCs) with enhanced immunosuppressive and trafficking capabilities for the treatment of graft-versus-host disease (GVHD) and inflammatory bowel disease (IBD).

The key objectives are to: 1) determine the mechanisms by which the engineered "CAR-MSCs" exert improved immunosuppression, 2) study the cellular trafficking of CAR-MSCs in preclinical models, and 3) optimize the signaling of CAR-MSCs. This 5-year project aims to create a new translatable cellular therapy strategy using engineered MSCs with enhanced targeting and immunosuppression compared to unmodified MSCs for treating GVHD and IBD. The award date is July 11, 2024, with a planned completion by May 31, 2029.

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