Project Grant R01AI179686

Award Date 7/17/24
Completion Date 6/30/29
Dollars Obligated $810K
Federal Grant Program
93.855
Assistance Type
Project Grant
Place of Performance
Atlanta, GA 30322, USA
Similar Awards
This $534,000 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research to develop wastewater surveillance systems for monitoring multidrug-resistant bacteria (MDRB). The key objectives are to: Establish standardized wastewater surveillance strategies to inform clinical infection control responses, using long-read metagenomics and novel bioinformatics to rapidly identify significant changes in...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) provides $1,144,714 to the University of Illinois to conduct research aimed at discovering novel antibiotics for gram-negative pathogens. The primary goals are to identify physicochemical traits that allow antibiotics to evade efflux pumps in E. coli, P. aeruginosa, and A. baumannii, and then apply this knowledge to develop at...
This federal Project Grant award, valued at $243,361.00 and running from August 15, 2024 to July 31, 2026, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant is funding a project by Rush University Medical Center in Chicago, Illinois to establish workflows for rapid and inexpensive whole genome sequencing (WGS) of Neisseria gonorrhoeae (NG) directly from urine, throat, and rectal...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) provides $237,750 to assess the environmental and health impacts of a citywide sanitation infrastructure upgrade in Indianapolis, Indiana. The study will collect and analyze surface water samples and flies for fecal indicator bacteria, enteric pathogens, antimicrobial resistance genes, and fecal source tracking markers before and after the sanitation...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $582,350 to the University of Illinois to conduct research on microbiota-mediated colonization resistance to Acinetobacter baumannii. The goal is to identify keystone gut microbial species that can synergize with a diverse microbiota to prevent colonization by this opportunistic pathogen, which poses a...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $212,169 to The Johns Hopkins University to advance mentorship and research capabilities related to combating antimicrobial resistant (AMR) infections. The award will enable the principal investigator to enhance their expertise in constructing site-directed mutants of key β-lactamase enzymes and integrating...
This $948,482 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research into the molecular mechanisms of the YbtPQ bacterial importer, a novel type of ATP-binding cassette (ABC) transporter found in uropathogenic E. coli. The primary goals are to define the substrate selectivity and inhibitory mechanisms of YbtPQ, as well as understand its unique structural motifs. Researchers at the University of...
The University of Chicago was awarded a $506,394 Project Grant by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) on January 24, 2025. The grant supports research to define the mechanisms by which bacterial cholesterol-dependent cytolysins can reorganize host cell organelles and activate the NLRP3 inflammasome signaling pathway, which plays a critical role in the immune response to bacterial infections. The research aims to...
This federal Project Grant award of $254,478 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to identify mechanisms of resistance to pathogen-specific antibacterial antisense compounds and develop strategies to overcome them. The award recipient, The University of Texas Southwestern Medical Center, will investigate resistance to these novel antibacterial compounds called...
This Project Grant award of $828,820 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research Program (CFDA 93.855) supports research to elucidate the molecular mechanisms by which the commensal bacterium Enterococcus faecalis can translocate across the intestinal epithelial barrier and cause systemic infections. The research aims to define how E. faecalis disrupts endoplasmic reticulum proteostasis and activates the unfolded...

This federal Project Grant award totaling $810,312.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will fund research to investigate environmental reservoirs and transmission dynamics of multi-drug resistant Enterobacterales (MDR ENT) in the Chicago area.

The key objectives are to: 1) Profile MDR ENT and mobile antibiotic resistance genes in Greater Chicago waterways to identify environmental reservoirs associated with community acquisition of MDR ENT; and 2) Assess risk factors for colonization and transmission of community-acquired MDR ENT among residents in high-risk regions. This will involve extensive environmental sampling, household surveys, and comprehensive genomic characterization of MDR ENT across environmental, animal, and human sources. The findings are expected to inform targeted interventions to reduce community exposure and transmission of these concerning antibiotic-resistant pathogens.

The project involves sub-awards to the Rush University Medical Center, University of Chicago, and Virginia Polytechnic Institute & State University to contribute specialized expertise in epidemiology, environmental microbiology, and genomic analysis. This collaborative research aims to address critical gaps in understanding the community-level spread of MDR ENT.

Generated 7/1/25, 3:37 AM