This federal Project Grant award of $534,000.00, awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 Allergy and Infectious Diseases Research program), will fund research at The Children's Hospital of Philadelphia (CHOP) to investigate the role of antigen location and peptide:MHCII complex density and half-life in driving CD4+ T cell differentiation. The research aims to test a model proposing that extracellular antigens generate a weak "Signal 1"...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $658,426 to The Children's Hospital of Philadelphia (CHOP) over a 5-year period from Dec 2024 to Nov 2029. The grant supports research to investigate the mechanisms by which chronic STAT3 signaling, a rare genetic condition, leads to impaired CD8 T cell function and increased susceptibility to both viral...
This federal Project Grant award for $820,623.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the genetic determinants regulating the master transcriptional regulator SPI1 in human germinal center B cells. The research aims to identify non-coding regulatory elements, delineate the effects of SPI1 coding variants on autoregulation and expression, and...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $586,250 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of Massachusetts Medical School (UMass Medical) to support research on the differentiation and regulation of TFH13 cells, a novel T cell subset that drives the production of high-affinity, pathogenic IgE antibodies in allergic diseases. The overarching goal is to elucidate the immunological requirements for...
This $693,465 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports a research project to map the development of T cell immunity in lymph nodes from infancy to adulthood. The key objectives are to: 1) Determine how the spatial organization of T cells changes in the lymph node throughout childhood; 2) Examine how the lymph node shapes the CD8+ T cell response to infection in...
This five-year, $196,992 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) supports research to study the role of the transcription factor FOXP3 in the development of regulatory T cells (Tregs) from induced pluripotent stem cells (iPSCs). The principal investigator, Dr. Gloria Yiu, will investigate methods to enhance endogenous FOXP3 expression in iPSCs and compare the...
This Project Grant award for $737,502.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to investigate the role of the WDFY4 protein in the activation and function of regulatory T cells (Tregs). The key objectives are to: 1) Determine the impact of WDFY4 on the T cell receptor (TCR) repertoire, particularly in Tregs, to identify self-reactive TCRs dependent on WDFY4; 2)...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) will provide $373,359 over 5 years to support a Physician Scientist Training Program in Immune Dysregulation at the University of Pennsylvania. The program aims to train the next generation of physician-scientists to study the root causes of immune dysregulation syndromes and develop novel approaches for their diagnosis,...
This federal Project Grant award, valued at $639,084 and issued by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the heterogeneity of naïve CD8 T cells and its impact on immune responses and T cell homeostasis. The research will investigate both mouse and human naïve CD8 T cells, with the goal of developing strategies to induce protective naïve CD8 T cell immunity...
The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $417,984 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Scripps Research Institute in La Jolla, California. The grant, with a performance period from March 7, 2025 to February 28, 2026, supports research aimed at identifying actionable targets for the selective induction of regulatory T cell (Treg) differentiation to facilitate the development of stem cell-based therapies...