Project Grant R01AG102624
- The National Institute on Aging awarded the University of Arizona a cooperative agreement totaling $6,348,351 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a first-in-human Phase 1A randomized, placebo-controlled safety and tolerability study of PNA5, a novel glycosylated angiotensin-(1-7) peptide and selective MAS receptor agonist designed to treat vascular cognitive impairment and dementia (VCID) and Alzheimer's disease-related dementias (ADRD). The study will...
- The National Institute on Aging awarded the University of California, San Diego $408,012 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop methods for improving central nervous system pharmacokinetics of targeted protein degraders through specialized assay workflows and prodrug chemistries. The research will establish dual-functional molecules that hijack endogenous molecular transport pathways to cross the blood-brain barrier, with early-stage application to...
- The National Institute on Aging awarded the University of Arizona $396,241 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a longitudinal, multi-modal study tracking neuroplasticity changes in preclinical and prodromal Alzheimer's disease stages using transcranial magnetic stimulation (TMS) integrated with blood and MRI biomarkers. The study employs TMS to assess non-invasive, repeatable neurophysiological measures of neuroplasticity and correlates these...
- The National Institute on Aging awarded the University of Arizona $616,013 on September 4, 2026, under the Aging Research program (CFDA 93.866) to conduct a Project Grant testing whether enhancing MET receptor tyrosine kinase signaling can rescue synaptic loss and reverse cognitive decline in an Alzheimer's disease mouse model. The research investigates the central hypothesis that synaptic degeneration in Alzheimer's disease can be mitigated by reactivating MET signaling in the adult brain....
- The National Institute on Aging awarded the University of Arizona $996,193 on July 15, 2026, under the Aging Research program (CFDA 93.866) to evaluate how small and large vessel cerebrovascular disease interact over time to contribute to Alzheimer's disease and related dementias risk. The project will examine how extracranial large vessels, intracranial large vessels, and cerebral small vessels interact across different patient populations, with particular attention to sex-specific...
- The National Institute on Aging awarded the Scripps Research Institute $2.613 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate a druggable mito-nuclear feedback mechanism that preserves mitochondrial and synaptic function in aging and Alzheimer's disease. The research focuses on elucidating how age and pathological tau destabilize a brain-specific mito-nuclear feedback loop that controls mitochondrial gene expression in response to acetyl-CoA...
- The National Institute on Aging awarded Arizona State University $655,917 under the Aging Research program (CFDA 93.866) on August 15, 2026, to develop and validate deep learning methods that enhance retinal color fundus photography image quality, automate retinal biomarker identification for Alzheimer's disease pathology, and enable scalable, cost-effective preclinical AD risk assessment. The project will create an unsupervised method using optimal transport-guided generative adversarial...
- The National Institute of Neurological Disorders and Stroke awarded the University of Arizona $427,625 on August 22, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop PNA5, an angiotensin-(1-7) glycopeptide therapeutic candidate to treat cognitive decline in Parkinson's disease dementia. The award funds preclinical research testing whether PNA5 mitigates cognitive deficits and pathology in mouse models of Parkinson's...
- The National Institute on Aging awarded Arizona State University $675,329 on May 1, 2026, under the Aging Research program (CFDA 93.866) to characterize cellular pathology and biomarkers in an Alzheimer's disease model developed through gene delivery in aged macaque monkeys. The research extends prior work conducted under a companion R24 grant in which the investigators developed a tauopathy model by injecting an adeno-associated virus carrying an aggregation-prone human tau variant...
- Federal Grant Award Summary The University of Arizona received a $3.03 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 30, 2025, with a completion date of September 29, 2029. Led by Principal Investigator Dr. Grilli, this research initiative focuses on developing and validating novel semantic memory assessment measures to detect early Alzheimer's disease (AD) pathology in cognitively unimpaired and mildly...
The National Institute on Aging awarded the University of Arizona $611,338 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop selective DYRK1A inhibitors for Alzheimer's disease treatment. The research targets dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) as a therapeutic intervention modulating tau, amyloid, and neuroinflammatory pathways in Alzheimer's disease. Prior work demonstrated that the DYRK1A inhibitor DYR533 improves behavioral and neuropathological features in multiple AD models while reducing pro-inflammatory cytokine levels, but mechanism-based safety studies revealed a significant cardiovascular toxicity liability through PDE3A inhibition and sub-optimal brain exposure kinetics. The current award funds development of a second-generation DYRK1A inhibitor addressing these liabilities. The award is a Project Grant with a period of performance from September 1, 2026, through May 31, 2031. Work is performed in Tucson, Arizona. The University of Arizona operates as the recipient under its Arizona Board of Regents business designation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $611.3k | 8/18/26 |