Project Grant R01AG099908
- The National Institute on Aging awarded the Trustees of Boston University $343,350 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and optimize personalized transcranial alternating current stimulation (TACS) with closed-loop precision modulation for memory enhancement in aging adults. The project grant (R01AG097619) runs through January 31, 2031, with work performed in Boston, Massachusetts. The funded research optimizes high-resolution TACS intervention...
- The National Institute on Aging awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) $357,000 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate endothelial pannexin1-induced inflammation in Alzheimer's disease. The research tests the hypothesis that amyloid-beta upregulates cerebral endothelial pannexin1 expression, which promotes vascular dysfunction and Alzheimer's disease progression through increased neuroinflammation and...
- The National Institute on Aging awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) a $8.296 million Cooperative Agreement on July 1, 2026, under the Aging Research program (CFDA 93.866) to develop and test an advance care planning educator video program for older adults and those with Alzheimer's disease and related dementias. The program addresses a documented gap between the medical care older Americans want when facing serious illness and the care they receive,...
- The National Institute on Aging awarded the University of California, Los Angeles $169,020 on August 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a clinical trial of repetitive transcranial magnetic stimulation (RTMS) targeting the posterior parietal lobe in Alzheimer's disease patients. The project, titled "Protocol for Maintaining and Improving Mental Status in Alzheimer's Disease (PROMIS-AD): A Study of Broad-Coil Parietal Repetitive Transcranial Magnetic...
- The National Institute on Aging awarded The Feinstein Institutes For Medical Research $460,625 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the mechanistic underpinnings of electrical trigeminal nerve stimulation for enhancing neuropsychological function in dementia. The project addresses neuropsychiatric symptoms—including anxiety and depression—that affect up to 80 percent of dementia patients and significantly contribute to cognitive decline and...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $660,000 on March 15, 2026, under the Aging Research program (CFDA 93.866) to develop deep learning–based image registration and morphometric analysis tools for structural MRI-derived biomarkers in Alzheimer's disease diagnosis. The project aims to improve the sensitivity and accessibility of longitudinal morphometric metrics derived from T1-weighted structural brain MRI scans—a non-invasive...
- The National Institute on Aging awarded The General Hospital Corporation (Massachusetts General Hospital) $129,330 on August 15, 2026, under the Aging Research program (CFDA 93.866) to develop artificial intelligence techniques for identifying cerebral amyloid angiopathy at early disease stages using multimodal MRI sequences. The recipient will integrate accessible MRI sequences—T1-weighted, T2-weighted, T2*-weighted gradient echo, fluid-attenuated inversion recovery, and diffusion imaging—to...
- The National Institute on Aging awarded Massachusetts General Hospital $3,174,899 on February 15, 2026, under the Aging Research program (CFDA 93.866) to develop cell therapy targeting restoration of circuit function in Alzheimer's disease. The award funds research into stem cell-based therapeutic strategies, specifically the transplantation of inhibitory interneuron progenitors to restore slow-wave brain activity disrupted in Alzheimer's disease and rescue sleep-dependent memory...
- The National Institute on Aging awarded Exqor Technologies Inc. $999,176 on September 22, 2025, under the Aging Research program (CFDA 93.866) to develop non-radioactive nanoprobes for magnetic resonance imaging of tropomyosin receptor kinase B (TrkB) in Alzheimer's disease. The project addresses early detection of decreased TrkB expression, which is implicated in impaired neurogenesis, synaptic damage, and neuronal death in Alzheimer's disease. The recipient is developing a two-part...
The National Institute on Aging awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) $889,728 on August 18, 2026, under the Aging Research program (CFDA 93.866) to develop circuit-based multi-focal neurostimulation targeting depression and memory in older adults with Alzheimer's dementia. The project combines transcranial direct current stimulation targeting the left prefrontal cortex to address depressive symptoms with transcranial alternating current stimulation at the left angular gyrus at 40 Hz gamma frequency to improve episodic memory. The approach leverages individualized electric field modeling to optimize multi-channel stimulation electrode placement and current parameters, implements active-sham protocols to strengthen double-blinding and control for peripheral stimulation effects, and delivers stimulation at home through remotely monitored caregiver-led administration. The award addresses a gap in treatment for older adults with co-occurring mild dementia due to Alzheimer's disease and depression, a highly prevalent combination that drives disability yet yields limited benefit from current interventions. The project targets the underlying altered function within specific brain circuits responsible for both depressive and memory symptoms. Performance occurs in Boston, Massachusetts. The period of performance runs through July 31, 2031. This is a Project Grant, an assistance type under the National Institute on Aging's mandate to support biomedical and behavioral research directed toward understanding aging, preventing and treating Alzheimer's disease, and addressing the diseases and special problems of aging populations.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $889.7k | 8/18/26 |