Project Grant R01AG099895
- Federal Grant Award Summary The University of Pennsylvania received a $164,190 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective November 27, 2025, with a completion date of May 31, 2030. The research project, titled "Modulating Synovial Mechanobiology to Mitigate Disease Progression in Osteoarthritis," will be conducted at the institution's Philadelphia, Pennsylvania facility. This award supports biomedical research...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pennsylvania $243,000 under the Aging Research program (CFDA 93.866) on September 5, 2025, for a project concluding May 31, 2030. This project grant supports biomedical research investigating the impact of frailty on disease relapse and therapy intensity in older adults with acute myeloid leukemia (AML), with emphasis on identifying biomarkers and optimizing treatment selection. The research...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded the University of Pennsylvania a Project Grant of $333,116 under the Aging Research program (CFDA 93.866) effective September 1, 2025, through August 31, 2026. This award supports biomedical research directed toward understanding aging processes and age-related diseases. The research project investigates the relationship between telomere dysfunction, aging, and intestinal stem cell (ISC) niche function, with the goal of...
- Federal Grant Award Summary The University of Pennsylvania received a $546,145 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective May 1, 2026 through March 31, 2031. This research initiative delivers scientific investigation into the molecular mechanisms of telomere function in muscle cells, specifically examining how telomere-associated...
- Federal Grant Award Summary The Ohio State University received a $787,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on August 15, 2025, with completion targeted for July 31, 2027. This award supports research investigating age-related changes in macrophage polarization and their effects on fracture healing outcomes in elderly patients. The research addresses a significant clinical gap, as aging is associated with increased...
- Federal Grant Award Summary Pennsylvania State University, doing business as Penn State Milton S. Hershey Medical Center, received a $1.948 million Project Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) awarded on September 1, 2025, with a completion date of August 31, 2028. The grant funds research into post-transcriptional regulation of gene expression during bone...
- Federal Grant Award Summary The National Institute of Arthritis and Musculoskeletal and Skin Diseases awarded the University of Pennsylvania a $857,127 Project Grant on June 3, 2025, under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to investigate mitochondrial respiration and growth plate chondrocyte biology. The research project, extending through April 30, 2030, examines how bioenergetic metabolism—specifically glycolysis and oxidative phosphorylation...
- Federal Grant Award Summary The University of Pennsylvania received a $214,223 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective March 5, 2026 through February 28, 2031. This K24 career development award supports the establishment and expansion of a high-quality mentorship program designed to train the next generation of research leaders focused on improving clinical care delivery for older adults. The primary deliverable is a...
- Federal Grant Award Summary The National Institute on Aging awarded the University of Pennsylvania a $2.8 million Project Grant under the Aging Research program (CFDA 93.866) for the five-year period from February 1, 2026, through January 31, 2031. The grant supports research on the epigenetics of aging and age-associated diseases, with particular focus on two mechanisms: chromostasis (homeostatic mechanisms that maintain dynamic chromatin stability) and the senescence-associated secretory...
- Federal Project Grant Award Summary The University of Pennsylvania received a $646,506 Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), effective September 5, 2025, through June 30, 2030. This award supports the development of dual-action nanoparticle-loaded microparticles designed to address osteoarthritis (OA) treatment through an innovative...
The University of Pennsylvania received a $723,105 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on May 15, 2026, with a completion date of February 28, 2031. This award supports research aimed at targeting Activin A signaling to enhance bone repair, addressing the clinical challenge of delayed or nonunion fractures that occur in 5-10% of fracture cases, with particular prevalence among geriatric populations. The research builds on single-cell RNA sequencing analysis identifying proliferative progenitor cells that express high levels of Activin A, a growth factor from the transforming growth factor-beta superfamily that stimulates mesenchymal progenitor cell proliferation and differentiation into bone and cartilage-forming cells. The project delivers scientific research findings and preclinical evidence regarding the mechanisms by which Activin A signaling enhances bone healing, utilizing murine fracture and drill hole injury models to validate the role of Activin A in bone regeneration. Products include characterization of how age-related declines in Activin A expression contribute to impaired fracture healing in aged individuals, comparative analysis of young versus aged periosteum responses, and potential therapeutic targets for developing new interventions to improve fracture healing outcomes. The research outcomes are intended to advance understanding of bone repair mechanisms and identify therapeutic strategies to address delayed healing complications associated with aging.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $723.1k | 5/14/26 |