Project Grant R01AG099750
Award Date 8/1/26
Completion Date 5/31/31
Dollars Obligated $872K
Federal Agency
Federal Grant Program
Assistance Type
Project Grant
Place of Performance
Covington, LA, USA
Similar Awards
- The National Institute on Aging, part of the Department of Health and Human Services, awarded Tulane University $874,974 on September 1, 2026, under the Aging Research program (CFDA 93.866) to study the effects of CSF1R blockade on brain aging and HIV-associated neurocognitive disorder using a macaque model. The project examines how neuroinflammation, myeloid dysregulation, and blood-brain barrier decline drive cognitive impairment in aging and HIV infection. The research uses a macaque model...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $422,125 to the Board of Regents of the University of Nebraska on June 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the roles of misfolded protein aggregates on latent HIV reservoirs in simian immunodeficiency virus–infected, antiretroviral therapy–treated aged rhesus macaques. The research examines how age-associated amyloid fibril deposition affects the reactivation and...
- The National Institute on Aging awarded Tulane University four hundred twenty thousand seven hundred fifty dollars on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of L1 retrotransposons in normal brain aging and Alzheimer's disease in vivo. The research tests whether chronic L1 retrotransposon expression contributes to Alzheimer's disease progression using mouse models of L1 retrotransposition and Alzheimer's disease. L1 is a repetitive genetic...
- The National Institute on Aging awarded Northwestern University $794,664 under the Aging Research program (CFDA 93.866) on July 15, 2026, to investigate senescence-associated pathways in people living with HIV who experience premature aging. The research targets novel mechanisms of healthy aging in HIV by examining senescence-associated glycan-degrading enzymes (β-galactosidase and sialidase) that degrade anti-inflammatory glycans on circulating glycoproteins, disrupting pathways that inhibit...
- The National Institute on Aging awarded Vanderbilt University Medical Center $519,500 on May 15, 2026, under the Aging Research program (CFDA 93.866) to examine epigenetic age acceleration and differences among immune cell populations in people with and without HIV. The research uses cryopreserved peripheral blood mononuclear cell samples and existing detailed cellular and clinical outcome data from 140 individuals (35 younger, ages 30–39, and 105 older, ages 50 and above) with and without...
- The National Institute on Aging awarded $616,284 to The Administrators Of Tulane Educational Fund, doing business as Tulane University, under the Aging Research program (CFDA 93.866) on August 1, 2026, to investigate long-term changes in blood proteomic whole-body and organ-specific biological aging clocks in response to calorie restriction interventions. The research builds on two long-term calorie restriction intervention studies—the POUNDS LOST trial and the CENTRAL trial—and will identify...
- The National Institute on Aging awarded the University of Miami $164,766 on September 5, 2026, under the Aging Research program (CFDA 93.866) to conduct research on T cell senescence-driven immune dysfunction in aging and HIV. The research will establish a complete T cell senescence-associated secretory phenotype (SASP) atlas using fluorescence-activated cell sorting and mass spectrometry, then evaluate plasma biomarkers of T cell senescence during physiologic aging and in people with HIV. The...
- The National Institute on Aging awarded Louisiana State University Health Sciences Center New Orleans $748,679 on August 5, 2026, under the Aging Research program (CFDA 93.866) to conduct an autopsy-based study examining the anti-inflammatory effects of cannabis on Alzheimer's disease-associated neuropathology in people living with HIV. The recipient will analyze full-body autopsy tissues collected from decedents with and without HIV-1 to characterize HIV-1 tissue reservoirs, assess cannabis use...
- The National Institute on Aging awarded Sri International $1.259 million under the Aging Research program (CFDA 93.866) on September 15, 2025, for a project grant investigating glymphatic magnetic resonance imaging and biomarker discovery in aging individuals living with HIV infection through August 31, 2027. The research examines dysfunction of the brain's waste clearance system (the glymphatic system) as a contributor to cognitive decline in older people with HIV. The project uses non-invasive...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $746,063 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate amyloid beta plaque formation and neuroinflammation in aging people with HIV. The award funds exploration of cell-specific transcriptional changes associated with early amyloid beta deposition in human brain, distinguishing compacted amyloid with early neuritic pathology from diffuse amyloid without neuritic change, and...