Project Grant R01AG099051
- The National Institute on Aging awarded University of Massachusetts Medical School $445,130 on January 1, 2026, under the Aging Research program (CFDA 93.866) to support research elucidating the mechanisms by which MS4A genes regulate neurodegeneration in Alzheimer's disease and related disorders. The research investigates how genetic deletion and polymorphisms of MS4A family genes—particularly MS4A6C, MS4A4A, MS4A4E, and MS4A6E—affect disease progression across multiple neurodegenerative...
- The National Institute on Aging awarded Rensselaer Polytechnic Institute $698,712 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate apolipoprotein E and reelin interactions in Alzheimer's disease pathology. The research tests the hypothesis that APOE E4 competes with reelin for receptor and heparan sulfate binding, thereby reducing protective reelin signaling and increasing Alzheimer's disease risk. Work includes mechanistic studies using split luciferase assays...
- The National Institute on Aging, a component of the Department of Health and Human Services, awarded Massachusetts Institute of Technology $596,050 on September 15, 2026, under the Aging Research program (CFDA 93.866) to investigate fuzzy coat dynamics of post-translationally modified tau aggregation. The project examines structural properties of tau, a microtubule-associated protein whose aggregation hallmarks Alzheimer's disease and twenty other neurodegenerative diseases. The research tests...
- The National Institute on Aging awarded Tufts Medical Center Parent, Inc. (doing business as Tufts Medical Center) $357,000 under the Aging Research program (CFDA 93.866) on September 1, 2026, to investigate endothelial pannexin1-induced inflammation in Alzheimer's disease. The research tests the hypothesis that amyloid-beta upregulates cerebral endothelial pannexin1 expression, which promotes vascular dysfunction and Alzheimer's disease progression through increased neuroinflammation and...
- The National Institute on Aging awarded Weill Medical College of Cornell University a $3.252734 million Cooperative Agreement (UG3AG098024) on April 1, 2026, to conduct a Phase 1A clinical trial of gene therapy for APOE4 homozygous Alzheimer's disease. The recipient will execute a safety and dose-ranging trial administering AAVRH.10HAPOE2CH—an adeno-associated virus vector carrying a modified protective APOE variant—via cerebrospinal fluid injection to APOE4 homozygotes with early-onset...
- The National Institute on Aging, under the Department of Health and Human Services, awarded $446,875 to the University of Pennsylvania on March 15, 2026, under the Aging Research program (CFDA 93.866) to identify short RNAs that prevent and reverse aberrant phase transitions of TAF15, an RNA-binding protein implicated in approximately 10 percent of frontotemporal dementia cases. The project, R21AG091143, funds research to develop short RNAs of 25 to 34 nucleotides that antagonize pathological...
- The National Institute on Aging awarded The Johns Hopkins University $427,625 under the Aging Research program (CFDA 93.866) on September 1, 2026, for research targeting glial cholesteryl ester accumulation as a treatment strategy for apolipoprotein E4–associated Alzheimer's disease. The research focuses on ACAT1/SOAT1, the enzyme that converts free cholesterol into cholesteryl esters for storage in lipid droplets within glial cells. The project proposes conjugating eflucimibe, a potent...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $1,613,176 on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the impact of M6A RNA modifications in Alzheimer's disease and tauopathies. The research will characterize N6-methyladenosine (M6A) RNA modifications and their downstream functional consequences in post-mortem brain tissue from subjects with Alzheimer's disease and other tauopathies, leveraging...
- The National Institute on Aging awarded $128,250 to Weill Medical College of Cornell University on August 5, 2026, under the Aging Research program (CFDA 93.866) to investigate modifiers of human microglia-neuron interplay in tau propagation in vivo. The research employs a human neuron-microglia chimera platform that integrates human neurons, astrocytes, and microglia into the mouse brain to model Alzheimer's disease and frontotemporal dementia pathology. Aim 1 investigates molecular...
- The National Institute on Aging awarded The Regents of the University of California, San Francisco $681,908 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate protective mechanisms of UFM1-dependent IRE1 signaling in tauopathies, with work performance in San Francisco, California through November 30, 2030. The project addresses tau protein aggregation in Alzheimer's disease and related tauopathies by elucidating molecular mechanisms linking the ufmylation pathway...
The National Institute on Aging awarded the University of Massachusetts Medical School $419,946 on September 1, 2026, under the Aging Research program (CFDA 93.866) for research into RNA interference-mediated modulation of apolipoprotein E, innate immune response, and tau pathology as a disease-modifying treatment for Alzheimer's disease. The funded research develops and tests small interfering RNA scaffolds that simultaneously target multiple genes implicated in Alzheimer's disease progression. The research panel includes fully chemically modified siRNAs targeting APOE, TAU, and JAK1 (a master regulator of interferon-gamma signaling), along with secondary siRNAs targeting immune and amyloid pathway genes. The work explores how silencing these targets individually and in combination affects amyloid clearance, tau pathology, and neuroinflammation in amyloid-driven Alzheimer's disease mouse models. The Khvorova Lab has optimized central nervous system-active multivalent siRNA scaffolds capable of silencing up to four genes simultaneously with potent, long-lasting effects exceeding 90% knockdown for multi-month periods in rodent central nervous systems and six to twelve months in human central nervous systems with minimal systemic exposure—a requirement critical for safe APOE modulation. This class of drug is anticipated to enter clinical trials in 2025. Work is performed at the University of Massachusetts Medical School in Worcester, Massachusetts. The period of performance runs from September 1, 2026, through June 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $419.9k | 9/1/26 |