Project Grant R01AG098488
- The National Institute on Aging, under the Department of Health and Human Services, awarded $467,181 to The Trustees of Columbia University in the City of New York on September 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research investigating how a life history of physical trauma contributes to aging and markers of aging, including inflammatory response and epigenetic markers, using African killifish (Nothobranchius furzeri) as a model organism. The research will...
- The National Institute on Aging awarded New York University $705,405 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how changes in nuclear physical properties during cellular senescence drive transcriptional and splicing dysregulation characteristic of aging. The funded research measures nuclear biophysical properties across multiple length scales using a toolkit including genetically encoded multimeric nanoparticles (nucGEMS, 40–50 nanometers), newly...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded The Trustees of Columbia University in the City of New York $149,190 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate the molecular mechanisms by which NBR2, a long non-coding RNA, contributes to ovarian aging. The research addresses female-specific health conditions through genome-wide association studies and functional genomic studies in human ovarian cell models. The...
- The National Institute on Aging awarded New York University $708,137 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate technologies for probing the biophysical properties of aging cells. The funded work centers on developing genetically encoded multimeric particles (GEMs) as high-throughput microrheology probes to measure the physical properties of cell interiors—particularly within organelles including the nucleus, cytoplasm, endoplasmic reticulum,...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $450,200 on May 15, 2026, under the Aging Research program (CFDA 93.866) to map age-dependent changes in primary sensory neurons and nociceptors. The recipient will deliver a systematic, cell-type-resolved map of how normal aging remodels peripheral sensory neurons housed in the dorsal-root ganglion (DRG). The project employs subtype-specific labeling via a recently published molecular-genetic...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $392,543 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate genetic regulators of microglial NF-kappa-B signaling in Alzheimer's disease. The award funds research into how genetic protective and risk factors for Alzheimer's disease regulate human microglial pro-inflammatory responses to oligomeric amyloid-beta. The project examines the genetic modifier SH3RF3,...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $100,228 on February 18, 2027, under the Aging Research program (CFDA 93.866) for epigenetic regulation research on microglial dysfunction in Alzheimer's disease. The award funds laboratory research investigating how the protein ARID5B regulates histone modifications that influence microglial identity and function in Alzheimer's disease pathogenesis. The recipient will use CRISPR/Cas9 and CRISPR...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $227,652 on August 6, 2026, under the Aging Research program (CFDA 93.866) to investigate mechanisms of DNA helicase B in ovarian and systemic aging. The research examines how reduced DNA helicase B (HELB) expression or function extends reproductive lifespan in women. The project integrates genome-wide association study analysis and functional genomic experiments to understand the relationship...
- The National Institute on Aging awarded Albany Medical College $246,000 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate inter-organelle dynamics during aging in eukaryotic cells. The work will characterize spatial contexts of inter-organelle communication using C. elegans as a model system to identify organellar signatures that develop during aging and proteostasis decline, establishing a platform to understand how aging impacts organelle interactions and...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $690,865 on January 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the relationship between mitochondrial oxidative phosphorylation capacity and resilience in human aging. The research leverages two unique human datasets: the MISBIE Study, which includes patients with and without genetically determined severe mitochondrial disease, and the Baltimore Longitudinal Study of...
The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $690,898 on September 15, 2026, under the Aging Research program (CFDA 93.866) to conduct functional genetic analyses of healthspan in humans. The recipient will identify shared genetic architecture underlying age-related diseases and aging-related traits, experimentally validate the regulatory roles of healthspan-associated non-coding variants and their target genes, and elucidate molecular mechanisms by which functional healthspan-associated variants influence gene expression and cellular aging processes. The research employs an integrative approach combining human genetic analyses, functional genomics, and human cell modeling to test the geroscience hypothesis—that genetic factors influencing fundamental aging mechanisms contribute to multiple age-related diseases and ultimately healthspan and lifespan. Performance occurs at Columbia University's Health Sciences Division in New York, New York, with a period of performance extending through May 31, 2031. This is a Project Grant, classified as assistance funding.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $690.9k | 9/2/26 |