The National Heart, Lung, and Blood Institute (NHLBI) awarded a $2,087,646 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to New York University School of Medicine. The grant, titled "Therapeutic Modulation of Atrial Remodeling," aims to develop a novel treatment for atrial fibrillation (AF) by leveraging all-trans retinoic acid (ATRA) to reverse the underlying atrial remodeling process. Through comparative transcriptomic analysis and single-nucleus...
This federal Project Grant award of $540,771 from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) aims to develop a personalized, socially aware, and equitable stroke risk prediction tool for patients with atrial fibrillation (AF). The key objectives are: (1) to discover new clinical and socioeconomic factors that influence stroke risk in AF patients, (2) to build novel machine learning-based models that incorporate social...
This $100,050 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) supports research to investigate the role of cardiometabolic drugs, including GLP-1 receptor agonists, SGLT-2 inhibitors, and metformin, as well as bariatric surgery, in reducing the burden of atrial fibrillation (AF). The research will utilize data from the Veteran Affairs nationwide electronic healthcare records to perform comparative...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), is funded under the Cardiovascular Diseases Research program (CFDA 93.837). The $769,761 award supports research at Weill Medical College of Cornell University to investigate the molecular mechanisms by which obesity leads to atrial fibrillation, a common heart rhythm disorder. The study aims to dissect the role of nicotinamide adenine dinucleotide...
The National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH), awarded a $393,750 Project Grant (CFDA 93.837 - Cardiovascular Diseases Research) to the University of California, Los Angeles (UCLA) to develop a population-based computational approach for predicting and preventing ventricular arrhythmias, a leading cause of sudden cardiac death. The research aims to: 1) Discover effective antiarrhythmic drug therapies by targeting dynamical parameters as...
The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), awarded a $299,604 Project Grant (R01HL177813) to Case Western Reserve University (CWRU) to develop and validate a novel "Transfer Volume Regression" method to enable quantitative clinical risk predictions for major cardiovascular events, including stroke, heart attack, heart failure, and death. The 4-year project aims to create a smart, standardized,...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a $764,817 Project Grant under the Cardiovascular Diseases Research (CFDA 93.837) program to the University of North Carolina at Chapel Hill (UNC-CH). The grant supports research to determine the mechanisms driving the coagulopathy and bleeding associated with acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia. Key focus areas include investigating the roles of the podoplanin-CLEC-2 pathway, the S100/annexin...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), aims to evaluate the utilization and clinical outcomes of left atrial appendage occlusion (LAAO) in older adults with atrial fibrillation and frailty. The $2,096,284 award to the Hebrew Rehabilitation Center, a non-profit hospital and research organization, will fund a 5-year study to determine the characteristics of older adults receiving...
This $650,000 Project Grant award from the National Science Foundation's Engineering program (CFDA 47.041) supports research at Columbia University aimed at advancing the understanding of blood clot dynamics in the left atrium of the heart. The project seeks to develop a computational model to investigate how the geometry and structural characteristics of the left atrium impact blood flow patterns and clot formation, which can lead to an increased risk of stroke in patients with atrial...
This $685,884 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of the C1 inhibitor protein in regulating coagulation and thrombosis, with the goal of identifying new therapeutic approaches for preventing venous thromboembolism. The research aims to: 1) Evaluate the molecular mechanisms by which C1 inhibitor regulates coagulation and venous thrombosis in mice, 2) Assess the impact of...