Project Grant R01AG097619
- Federal Project Grant Award Summary The National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), awarded a $441,612 project grant to the Trustees of Boston University (Boston University Medical Campus) effective May 15, 2025, with a completion date of January 31, 2030. This research initiative investigates the relationship between Life's Essential 8 (LE8)—a quantified set of modifiable lifestyle and clinical risk factors—and digital cognitive markers in predicting...
- Federal Project Grant Award Summary Boston University Medical Campus received a $636,342 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 1, 2025 through April 30, 2030. This award supports multiscale modeling and empirical studies investigating normal and pathological brain aging, specifically examining myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the neocortex as common hallmark changes in both...
- Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $327,000 Project Grant to the Trustees of Boston University (Boston University Medical Campus) on September 5, 2025, with an ultimate completion date of August 31, 2027. This research initiative aims to identify heterogeneous cognitive trajectories in preclinical Alzheimer's disease through digital phenotyping methodologies. The project leverages multimodal data integration,...
- Federal Project Grant Award Summary The National Institute on Aging awarded Boston University Medical Campus a $4.27 million project grant under the Aging Research program (CFDA 93.866) effective June 1, 2025 through May 31, 2027. This award funds continued research on the consequences of exposure to repetitive head impacts (RHI) across the human lifespan, with emphasis on understanding the neuropathological mechanisms linking RHI to neurobehavioral symptoms, cognitive impairment, Alzheimer's...
- Federal Project Grant Award Summary Boston University Medical Campus received a $147,486 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 19, 2025, with completion scheduled for November 7, 2026. This award supports functional epitranscriptomic profiling research investigating N6-methyladenosine (m6A) RNA modifications in Alzheimer's disease. The research deliverables include identification of m6A-modified RNA sites and...
- Federal Project Grant Award Summary The National Institute on Aging awarded The Washington University a $2.63 million Project Grant under the Aging Research program (CFDA 93.866) beginning September 1, 2025, with completion scheduled for August 31, 2029. This research initiative investigates age-related deficits in episodic memory for both content and structure of naturalistic events, with the objective of improving early detection of cognitive decline in at-risk older adults before...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Tufts University School of Medicine a $470,000 Project Grant under the Aging Research program (CFDA 93.866) on February 1, 2026, with a completion date of January 31, 2028. This grant funds research titled "Elucidating the Interplay Between AD Genetic Variants Using Human iPSC-Derived Brain Cells," which investigates the genetic mechanisms underlying Alzheimer's disease (AD). Given that AD has an estimated...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $10.4 million Project Grant to the Regents of the University of Michigan (Office of Research and Sponsored Projects) under the Aging Research program (CFDA 93.866) to conduct the first clinical study evaluating personalized brain stimulation as a treatment for Posterior Cortical Atrophy (PCA), a neurodegenerative condition typically caused by Alzheimer's disease. The research deliverables include the development and...
- Federal Project Grant Award Summary Northeastern University received a $705,385 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective April 1, 2025, through August 31, 2030. This award supports a large-scale research study examining mediators and moderators of executive function training in older adults aged 60 and above. The research addresses a critical gap between commercial "brain training" marketing claims and...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Trustees of Boston University a project grant of $848,993 on September 15, 2025, under the Aging Research program (CFDA 93.866) to investigate transfer RNA (tRNA) epitranscriptome dysfunction in Alzheimer's disease and related dementias (ADRD). The research will examine how modifications to tRNA molecules and their functional availability affect protein synthesis in degenerating brains, with the ultimate completion date of...
The National Institute on Aging (NIA) awarded Boston University $343,350 on February 1, 2026, under the Aging Research program (CFDA 93.866) to develop and validate optimized transcranial alternating current stimulation (TACS) protocols for memory enhancement in aging adults. The five-year project, concluding January 31, 2031, will deliver a personalized, connectivity-guided closed-loop TACS system designed to improve memory performance and address cognitive decline associated with Alzheimer's disease and related dementias. The research will produce multiple deliverables including dose-response optimization data comparing six TACS protocols with varying stimulation patterns (continuous versus patterned) and application schedules (one, three, or five consecutive days), comprehensive cognitive assessment findings measuring working memory capacity, interference suppression, and long-term memory recognition at baseline and multiple follow-up intervals, and neurobiological mechanism analysis utilizing multimodal imaging (EEG and functional MRI) to identify theta-gamma phase-amplitude coupling and synchronization biomarkers. This project advances the NIA's mission by generating evidence-based, non-invasive neuromodulation interventions with direct applicability to aging populations experiencing memory impairment. The research will establish clinically actionable TACS protocols and identify neurobiological predictors of treatment response, positioning the developed closed-loop system as a potential therapeutic tool for cognitive enhancement and dementia prevention in older adults.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $343.4k | 1/29/26 |