Project Grant R01AG097202
- This federal Project Grant award from the National Institute of Mental Health (CFDA 93.242 Mental Health Research Grants) provides $3,613,504 to the Icahn School of Medicine at Mount Sinai to investigate the role of the NLRP3 inflammasome in HIV-induced neuroinflammation and its impact on HIV persistence in the central nervous system (CNS). The 4-year project aims to: 1) elucidate the link between HIV-1 infection and NLRP3 inflammasome activation in the CNS using brain organoid and humanized...
- The Icahn School of Medicine at Mount Sinai received a $145,566 Project Grant from the National Institute on Aging (CFDA 93.866 Aging Research) on December 13, 2024. This federal grant supports research to understand how the brain accumulates and links cognitive maps over a lifetime, which is critical for developing interventions to address cognitive decline. The research aims to elucidate the neuronal coding deficits underlying age-related cognitive impairments, with the goal of informing the...
- This federal Project Grant award of $680,334.00 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to elucidate the molecular mechanisms and cellular players driving age-associated pro-tumoral myelopoiesis. The research will involve high-dimensional profiling of tumors from an early-stage lung cancer patient cohort, multi-omics phenotyping of myeloid cells and progenitors from young and aged patients and healthy donors, as well as complex bone marrow experiments. The...
- This $745,765 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the Icahn School of Medicine at Mount Sinai (ISMMS) in New York aims to investigate the effects of Alzheimer's disease (AD) risk genes and aging on human microglia activity and lipid metabolism. The key focus is on understanding how genetic variants associated with increased AD risk or longevity may impact microglia's ability to clear cholesterol/lipid-rich cellular debris, a critical...
- This Project Grant award of $789,664.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research initiative at the Icahn School of Medicine at Mount Sinai to characterize the effect of aging on the cellular microenvironment of the human lung and peripheral blood. The project combines single-cell RNA sequencing and spatial transcriptomics profiling to analyze cell composition, gene expression, and regulatory changes across different age groups. The goal is to...
- The National Institute on Aging (NIA) awarded a $422,500 Project Grant (CFDA 93.866) to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on the underlying drivers and consequences of high out-of-pocket spending for older adults with serious illness. The project aims to examine how insurance generosity affects high out-of-pocket spending and associated burdensome care, such as emergency department reliance, days away from home, and in-hospital death, as well as...
- This Project Grant award, valued at $428,493.00, was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The purpose of the award is to characterize and predict comorbidity cascade among men and women with and without HIV by leveraging data from the MACS/WIHS Combined Cohort Study (MWCCS) and electronic medical records. The key products and services to be delivered under this 2-year award, with an end date of August 31, 2027, include:...
- The U.S. Department of Health and Human Services, National Institutes of Health awarded a $462,454 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the Icahn School of Medicine at Mount Sinai. The award, which runs from August 2025 to June 2027, will fund research to characterize DNA methylation dynamics in trisomy 21-associated hematopoiesis and leukemia. Key objectives include mapping DNA methylation, chromatin accessibility, and RNA expression patterns in...
- The U.S. Department of Health and Human Services, through the Trans-NIH Research Support program (CFDA 93.310), awarded a $267,000 Project Grant to the Icahn School of Medicine at Mount Sinai. This award, effective from June 9, 2025 to June 8, 2027, will fund a pragmatic pilot feasibility trial to test the hypothesis that point-of-care testing for gonorrhea and chlamydia can improve HIV testing, pre-exposure prophylaxis (PrEP) counseling, and PrEP delivery among adolescents seeking sexually...
- This federal Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), will support research to investigate the role of chaperone-mediated autophagy (CMA) in cellular senescence and aging. The $147,486 award, made on December 3, 2024, will fund a project at the Albert Einstein College of Medicine in Bronx, NY that aims to understand how changes in CMA activity during aging contribute to the persistence of unresolved cellular senescence...
This federal Project Grant award of $703,644 was provided by the National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) and is effective from September 19, 2025 through June 30, 2030. The grant was awarded to the Icahn School of Medicine at Mount Sinai (ISMMS) to conduct research on the effects of clonal hematopoiesis, epigenetic changes, social determinants of health, and behavioral risk factors as predictors of accelerated aging in people living with HIV (PWH). The research aims to better understand the drivers of accelerated aging in this population in order to develop interventions to improve healthspan. ISMMS is a leading academic medical center with expertise in HIV research and will leverage its diverse patient cohort through the CFAR Network of Integrated Clinical Systems to carry out this comprehensive investigation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $703.6k | 9/18/25 |