Project Grant R01AG095618
- This Project Grant award of $506,404.00 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to investigate mechanisms of local and global epigenetic changes that drive senescence and aging-associated phenotypes. Key research objectives include: Examining how enhancers are rewired during senescence and aging, focusing on large enhancer communities or "cliques" and identifying transcription factors that drive their formation....
- This federal Project Grant award of $3,101,237.00 was provided by the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, under the Aging Research federal grant program (CFDA 93.866). The funding supports a research project investigating the mechanisms linking persistent DNA damage to immune responses and hematopoietic stem and progenitor cell function in the context of aging and DNA repair deficiency. Key objectives of the project include: 1) elucidating...
- This federal Project Grant award for $1,249,147.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant is a collaborative effort between Epicypher, Inc., a biotechnology company in Durham, North Carolina, and Dr. Nicolas Young of Baylor College of Medicine to develop a novel platform called AgingPTM for studying aging-associated combinatorial histone post-translational modifications (ACPTMs) in tissue. This platform is intended to...
- This National Institute on Aging (CFDA 93.866 Aging Research) Project Grant award of $412,500 to the Trustees of Boston University (Boston University Medical Campus) will fund research to investigate the "vicious cycle" between disruption of chromatin architecture, activation of retrotransposable elements (RTEs), and misexpression of CpG island-deficient genes during the aging process. The research aims to validate the mutual activation between chromatin architecture disruption and RTE...
- This $522,167 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research into the "Mechanisms of rDNA Instability During Aging" at the University of Virginia. The project will investigate the role of the FOB1 protein and the RNA Polymerase I transcription factor UAF in regulating double-strand breaks and recombination at the ribosomal DNA locus, a key driver of genomic instability and aging. The research will utilize innovative techniques...
- This $147,486 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) supports research to investigate the role of chaperone-mediated autophagy (CMA) in cellular senescence and its contribution to aging. The research aims to understand: 1) if CMA activity changes upon induction of senescence, 2) if CMA modulates senescence kinetics and by what mechanism(s), 3) if CMA is required for senescent cell clearance, and 4) if restoring CMA activity...
- This $2,991,725 Project Grant award, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research into the role of reactive oxygen species as modulators of lifespan and age-related diseases. The 4-year project, which commenced on September 1, 2025, aims to investigate a novel longevity paradigm in C. elegans that is triggered by early-life oxidative stress and mediated by changes in the epigenetic landscape. The research will examine the conserved mechanisms...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- This federal Project Grant award of $437,375.00 was provided by the National Institute on Aging (part of the U.S. Department of Health and Human Services) under the Aging Research program (CFDA 93.866). The grant supports research at the University of California, San Diego (UCSD) to investigate the role of the NEK7 protein in suppressing inflammation and adverse cardiac remodeling in the aging heart. Key objectives include determining if NEK7 activity decreases with aging, assessing NEK7's...
- This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
This Project Grant award, valued at $647,866.00 and provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the epigenetic regulation of nuclear cGAS activity and its role in aging-related inflammation. The key objective is to understand how aging-related changes in histone acetylation patterns and associated chromatin-binding proteins, such as BRD4, activate the innate immune sensor cGAS and contribute to chronic inflammation during aging. The research project will be conducted by the University of North Carolina at Chapel Hill over a period of approximately 5 years, from August 2025 to May 2030. The findings from this grant have the potential to introduce a new paradigm for understanding the mechanisms by which nuclear cGAS drives aging-related diseases and could inform the development of therapeutic strategies targeting histone acetylation and BRD4 to control inflammation.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $647.9k | 8/6/25 |