Project Grant R01AG095089
- The National Institute on Aging (NIA) awarded a $442,750 Project Grant (CFDA 93.866) to Duke University to conduct research on using heterochronic (age-mismatched) hepatocyte transplantation to rejuvenate the aged liver. The research aims to understand how transplanting young hepatocytes into old livers, and vice versa, can influence liver function, cellular composition, and the plasma proteome. Key objectives include measuring changes in liver function markers, analyzing the liver's cellular...
- This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $466,125 to Weill Medical College of Cornell University to study the effects of alcohol use on liver aging in the elderly population. The award period runs from August 1, 2025 to July 31, 2027. The key objectives of the project are to: 1) Examine if mice with a liver-specific knockout of the retinoic acid receptor beta (RARB) gene age more rapidly and if ethanol increases their rate of...
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $576,723 Project Grant under the Aging Research program (CFDA 93.866) to The Washington University in Missouri. This 5-year grant, awarded on August 5, 2025, supports research to determine the role of senescent cancer-associated fibroblasts (SenCAFs) in breast cancer progression. The key objectives are to: 1) Evaluate the organ-specific effects of SenCAFs on metastatic breast cancer, 2)...
- This Project Grant award of $610,836, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), supports research to investigate the contribution of mitonuclear interactions to aging and age-associated neurodegenerative diseases such as Alzheimer's disease. The research will leverage two new technological advances - MTDNA editing using DDCBE base editors and biobank-scale analysis of MTDNA copy number and heteroplasmy - to systematically study how...
- This federal Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $646,739.00 in funding to Cedars-Sinai Medical Center to investigate the molecular mechanisms underlying the role of hepatic stellate cells (HSCs) in promoting liver metastasis, particularly in the context of metabolic dysfunction-associated steatotic liver disease (MASLD). The key research objectives are to: 1) examine the regulatory mechanism and functional role of extra-tumoral...
- The National Institute on Aging (NIA) awarded a $405,849 Project Grant (CFDA 93.866 - Aging Research) to the Keck Graduate Institute of Applied Life Sciences to investigate the impact of obesity-induced hepatic amyloid beta dysregulation on Alzheimer's disease pathology. The key objectives are to: Examine the relationship between changes in peripheral and hepatic amyloid beta with brain amyloid beta load and Alzheimer's disease pathology in Alzheimer's disease mice fed a high-fat/high-sugar...
- This $846,358 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to build a research platform to assess the senescence-associated secretory phenotype (SASP) in vivo. The goal is to elucidate the molecular identity of the SASP secretome and develop biomarkers to distinguish senescence and SASP signatures across different tissues. To accomplish this, the award will leverage a novel SASP-ER platform that permits conditional tagging of secreted proteins in...
- The Project Grant award of $300,000.00 from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) will support a study on the epidemiology of the gut-liver axis and its relationship to hepatocellular carcinoma (HCC) risk in a multiethnic liver cirrhosis cohort. The study aims to expand the existing Microbiome, Microbial Markers, and Liver Disease (M3LD) cohort by enrolling approximately 1,000 participants with liver cirrhosis, with a focus on...
- This federal Project Grant award, valued at $463,625.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The grant will fund research conducted by the Icahn School of Medicine at Mount Sinai to better understand the relationship between age and the lung adenocarcinoma tumor microenvironment. The research aims to use advanced single-cell sequencing and spatial analysis technologies to characterize how age affects the cellular...
This Project Grant awarded by the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, aims to study the effects of aging on the development of metabolic dysfunction associated steatohepatitis (MASH) and its progression to hepatocellular carcinoma (HCC). The $633,393 award, effective January 1, 2026 through December 31, 2030, will support research by the Palo Alto Veterans Institute for Research (Pavir) to investigate how age-related changes in the SHC adaptor proteins impact mitochondrial function, lipid metabolism, and the extracellular matrix in promoting MASH-driven HCC. The project will utilize dietary interventions, genetic models, and small-molecule SHC inhibitors to evaluate metabolic and matrix-related mechanisms underlying the increased susceptibility of older patients to MASH-associated liver cancer.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $633.4k | 12/22/25 |