Project Grant R01AG094809
- The National Institute on Aging awarded Brown University $438,625 for Project Grant R21AG095984 on June 1, 2026, under the Aging Research program (CFDA 93.866). The project investigates the quiescence-senescence continuum hypothesis, examining how cellular quiescence—a reversible state of cell cycle arrest—and senescence—an irreversible form of arrest—exist along a dynamic continuum rather than as distinct states. The research will identify which hallmarks of senescence are shared with quiescent...
- The National Institute on Aging awarded the University of Massachusetts Medical School $452,783 on September 1, 2026, under the Aging Research program (CFDA 93.866) to develop genetically encoded intrabodies that inhibit individual enzymatic domains of retrotransposons in order to define retrotransposon function in synaptic development. The project addresses a critical gap in functional genomics: traditional loss-of-function approaches such as gene knockout and RNA interference cannot decouple...
- The National Institute on Aging awarded Tulane University four hundred twenty thousand seven hundred fifty dollars on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of L1 retrotransposons in normal brain aging and Alzheimer's disease in vivo. The research tests whether chronic L1 retrotransposon expression contributes to Alzheimer's disease progression using mouse models of L1 retrotransposition and Alzheimer's disease. L1 is a repetitive genetic...
- The National Institute on Aging, within the Department of Health and Human Services, awarded Trustees of Boston University $343,350 on May 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the contribution of genes repressed by endogenous double-stranded RNA-derived small RNAs to lifespan extension. The research focuses on major sperm protein genes repressed by small RNAs and argonaute proteins expressed in the spermatogenic germline, building on prior findings that high...
- The National Institute on Aging awarded The Scripps Research Institute $645,242 on July 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on chemical modulation of proteostasis to promote longevity and healthy aging. The award funds development of chemical and computational tools to selectively attenuate polysome-mediated translation in vivo, quantify protein conformational changes across the neuronal proteome with age, and assess healthy aging and behavior in...
- The National Institute on Aging awarded the University of Pennsylvania $2,809,832 on February 1, 2026, under the Aging Research program (CFDA 93.866) to investigate epigenetic mechanisms driving cellular aging and age-associated disease. The award funds four integrated research projects examining chromatin homeostasis ("chromostasis") and senescence-associated secretory phenotype (SASP) in aging tissues. The research hypothesizes that age-related epigenetic changes result from...
- The National Institute on Aging awarded Yale University $544,318 under the Aging Research program (CFDA 93.866) on June 1, 2026, to conduct research on immunometabolic regulation of inflammaging by nerve-associated macrophages (NAMs). The project investigates how nerve-associated macrophages—a subset of macrophages residing on sympathetic nerve fibers—regulate the sympathetic nervous system and innate immune response to control chronic inflammation associated with aging. The research addresses...
- The National Institute on Aging awarded New York University $705,405 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how changes in nuclear physical properties during cellular senescence drive transcriptional and splicing dysregulation characteristic of aging. The funded research measures nuclear biophysical properties across multiple length scales using a toolkit including genetically encoded multimeric nanoparticles (nucGEMS, 40–50 nanometers), newly...
- The National Institute on Aging awarded Yale University $1.416 million on May 15, 2026, under the Aging Research program (CFDA 93.866) to investigate cell size inheritance and innate immune memory, with performance through April 30, 2031, in New Haven, Connecticut. The funded research examines how enlarged immune cells—specifically monocytes and mast cells—can maintain proliferative capacity and immune surveillance without transitioning into senescence, a hallmark of aging. The work centers on...
- The National Institute on Aging awarded The Salk Institute for Biological Studies $1.359 million on February 15, 2026, under the Aging Research program (CFDA 93.866) to characterize activity-dependent changes to neuronal populations in the spinal dorsal horn during aging and determine functional consequences for sensorimotor behaviors. The research selectively perturbs activity in different classes of cutaneous afferent neurons to identify inputs that support cell survival in adult mice,...
The National Institute on Aging awarded Brown University $489,408 under Project Grant R01AG094809 on August 1, 2026, to investigate the mechanisms by which the human LINE-1 retrotransposon contributes to aging-related inflammation and senescence. The funded research examines LINE-1's dual activity in driving sterile inflammation and the senescence-associated secretory program (SASP) through two primary investigative pathways: cytosolic cDNA synthesis that activates innate immune signaling via cGAS/STING and the interferon-I response, and nuclear-mediated pathogenic activities. Specific Aim 1 will determine the contributions of both nuclear and cytoplasmic LINE-1 activities to senescence by manipulating LINE-1 expression through genetic tools and inhibitors in primary fibroblasts, assessing the roles of the ORF1P RNA-binding chaperone and the ORF2P reverse transcriptase enzyme. Specific Aim 2 will characterize ORF2P RNA properties and activities. The award supports research conducted in Providence, Rhode Island over a five-year period of performance through July 31, 2031. The Aging Research program (CFDA 93.866) funds biomedical, social, and behavioral research directed toward understanding aging processes and age-related diseases, with particular emphasis on Alzheimer's disease and related dementias.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $131.9k | 8/14/26 | ||
| Not listed | $357.5k | 7/20/26 |