Project Grant R01AG094755
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $684,567.00 under the Aging Research program (CFDA 93.866) on March 1, 2026, for a four-year methodology research project extending through December 31, 2029. This R01 resubmission grant supports the development and validation of 64Cu-Fibrin-Binding-Probe-8 positron emission tomography (FBP8 PET) imaging technology for detecting and quantifying pathological fibrin in the brain...
- Federal Grant Award Summary Massachusetts General Hospital received a $660,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on March 15, 2026, with a completion date of February 28, 2029. The award supports development of deep learning-based tools and methodologies to improve the accuracy and accessibility of Alzheimer's disease (AD) diagnosis through structural magnetic resonance imaging (MRI) analysis. Specifically, the project will develop...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $975,148 on May 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the role of reactive astrocytes in tau protein propagation and clearance in Alzheimer's disease. The research project, which extends through February 28, 2030, will generate scientific knowledge regarding the mechanisms by which glial fibrillary acidic protein (GFAP) upregulation in astrocytes may...
- Federal Project Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital a $258,660 Project Grant (CFDA 93.866 – Aging Research program) effective June 15, 2025, through March 31, 2030, to develop and validate a machine learning-based framework for early detection and prognostication of Alzheimer's Disease and Related Dementias (ADRD). The project deliverables include the creation of a multi-modal biomarker integration system that combines digital biomarkers...
- Federal Grant Award Summary The National Institute on Aging awarded a $677,276 Project Grant to Massachusetts General Hospital (The General Hospital Corporation) on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct positron emission tomography (PET) imaging research on alpha-synuclein pathology. The research project, which extends through January 31, 2031, focuses on developing and validating [11C]SY08 as a novel PET imaging tracer to differentiate and diagnose...
- Federal Grant Award Summary The National Institute on Aging awarded University of Maryland, Baltimore a $589,154 Project Grant under the Aging Research program (CFDA 93.866) effective February 1, 2026, through January 31, 2031. This research project develops and validates a normalized cerebrovascular reactivity (NCVR) magnetic resonance imaging technique to improve detection of vascular contributions to cognitive impairment in small-vessel disease patients. The project addresses a critical gap...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Henry Ford Health + Michigan State University Health Sciences a Project Grant totaling $3,062,355 under the Aging Research program (CFDA 93.866) to advance understanding of cerebral waste clearance mechanisms during Alzheimer's disease progression. The research initiative, spanning from September 15, 2025 through August 31, 2029, will optimize and validate detection of microvessels within the cerebral vascular,...
- Federal Project Grant Award Summary Massachusetts General Hospital received a $1.73M Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded February 15, 2026, with completion by January 31, 2031. This research project will conduct a comprehensive four-year longitudinal study investigating the clinical spectrum and societal impact of cognitive impairment, Alzheimer's disease, and related dementias (ADRD) among older people living with HIV (PWH) in Uganda....
- Federal Project Grant Award Summary The National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), awarded a $643,089 project grant to the University of Massachusetts Medical School to conduct an objective assessment of medication self-administration (MSA) as an early indicator of cognitive impairment and Alzheimer's disease and related dementias (ADRD). Commencing September 30, 2025, and concluding August 31, 2026, the research leverages the Framingham Heart Study cohort...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $459,250 under the Aging Research program (CFDA 93.866) on June 1, 2025, for a two-year project extending through May 31, 2027. This project grant supports longitudinal research investigating the mechanisms by which stress and resilience influence cognitive aging and Alzheimer's disease (AD) progression. The research will analyze existing data from two natural history,...
The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $670,530 Project Grant effective April 15, 2026, through March 31, 2031, under the Aging Research program (CFDA 93.866). The award supports research to develop and optimize advanced high-resolution magnetic resonance imaging (MRI) methods for noninvasively tracking cerebrospinal fluid (CSF) flow and amyloid-beta (Aβ) dynamics through perivascular spaces (PVS) in the brain. The research aims to provide direct evidence of CSF-mediated amyloid-beta clearance in healthy brains and identify disruptions during Alzheimer's disease pathogenesis, potentially informing therapeutic strategies targeting the glymphatic system for amyloid-beta removal. The project encompasses three specific aims: (1) development and optimization of novel MR mapping schemes to detect CSF flow dynamics through PVS and ventricles with enhanced resolution and rapid, high signal-to-noise ratio sampling methods; (2) identification of soluble amyloid-beta 42 (Aβ42) dynamics in CSF using MRI and two-photon microscopy; and (3) additional research objectives to validate how amyloid plaque deposition at the PVS impairs protein exchange between interstitial fluid and CSF. These research deliverables are being conducted at Massachusetts General Hospital's Research Management Division in Charlestown, Massachusetts.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $670.5k | 4/13/26 |