Project Grant R01AG093939
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant totaling $804,450 (awarded June 1, 2025, with completion targeted for March 31, 2030) under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the molecular mechanisms underlying Apolipoprotein E4 (APOE4)-driven pathogenesis in Alzheimer's disease (AD). The research will focus on targeting the growth factor protein NELL2 (Neural...
- Federal Grant Award Summary The National Institute on Aging awarded J. David Gladstone Institutes a Project Grant of $790,288 (awarded February 15, 2026, with completion by November 30, 2030) under the Aging Research program (CFDA 93.866) to conduct genetic research on the 17q21.31 MAPT locus associated with Alzheimer's disease and related dementias. The primary deliverable is a comprehensive genetic dissection study utilizing statistical genetics and machine learning methodologies to identify...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a $1,459,072 Project Grant on August 1, 2025, under the Aging Research program (CFDA 93.866) to investigate inhibitory neuron dysfunction in Alzheimer's disease (AD). The research will develop and implement innovative methodologies to monitor and manipulate two distinct inhibitory interneuron cell populations—parvalbumin (PVALB) and somatostatin (SST) cells—in both wildtype and AD-knock-in...
- Federal Grant Award Summary J. David Gladstone Institutes received a Project Grant award of $817,357 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 15, 2025, with a completion date of March 31, 2030. The award supports research applying novel machine learning (ML) approaches to behavioral analysis and brain signal integration in humanized Alzheimer's disease (AD) models. The primary deliverable involves validation and development of a...
- Federal Grant Award Summary The J. David Gladstone Institutes received a $630,496 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period June 1, 2025, through March 31, 2030. The award funds research investigating proteostasis dysfunction, neuroinflammation, and neurodegeneration in frontotemporal dementia (FTD) caused by GRN (granulin) haploinsufficiency. The research will examine how GRN deficiency impairs the autophagy/lysosomal...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant of $793,777 on June 17, 2025, under the Aging Research program (CFDA 93.866) to conduct research on mitochondrial deoxyribonucleic acid (DNA) compaction and the accumulation of mutations with age and stress. The primary deliverable is a comprehensive scientific investigation utilizing innovative long-read sequencing approaches to quantify DNA accessibility, mutations, and...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Regents of the University of California, San Francisco $805,573 under the Aging Research program (CFDA 93.866) on September 15, 2025, with a completion date of June 30, 2030. This Project Grant supports comprehensive biomedical research investigating the impact of N6-methyladenosine (M6A) RNA modifications in Alzheimer's disease and related tauopathies. The research deliverables include identification of specific RNA...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Scripps Research Institute a Project Grant of $878,190 under the Aging Research program (CFDA 93.866) for research investigating a druggable mito-nuclear feedback mechanism that preserves mitochondrial and synaptic function in aging. The award, issued September 15, 2025, with a completion date of May 31, 2030, supports research examining how mitochondrial decline contributes to Alzheimer's disease and related dementias...
- Federal Grant Award Summary The National Institute on Aging awarded a $610,836 Project Grant to the Broad Institute of MIT and Harvard (effective September 1, 2025, through May 31, 2030) under the Aging Research program (CFDA 93.866) to conduct systematic genetic research on mitonuclear interactions in aging and neurodegenerative diseases. The research will leverage two technological advances—mitochondrial DNA (mtDNA) editing using DDCBE base editors and biobank-scale analysis of mtDNA copy...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $1.58 million Project Grant on March 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research characterizing microvascular impairment in adults with elevated genetic risk for Alzheimer's disease. The research initiative, which extends through January 31, 2030, investigates the physiological mechanisms through which the apolipoprotein E-epsilon 4 (APOE-E4) allele—the...
The National Institute on Aging (NIA) awarded J. David Gladstone Institutes $801,193 under the Aging Research program (CFDA 93.866) on February 15, 2026, to support a five-year research project extending through January 31, 2031. The primary deliverable is a comprehensive scientific investigation into how the APOE4 allele disrupts energy metabolism in the context of Alzheimer's disease (AD). The research aims to identify the cellular and molecular mechanisms by which APOE4 reprograms brain energy metabolism from mitochondrial respiration toward glycolysis and the production of toxic metabolites, ultimately contributing to neurodegeneration. The project will produce research findings and data through two specific aims: (1) utilizing live imaging and mass spectrometry to measure metabolic fluxes in mouse models and determine how APOE4 disrupts energy metabolism and generates toxic metabolites; and (2) employing magnetic resonance spectroscopic imaging to assess metabolic rewiring and toxic metabolite production in human subjects with normal cognitive function and those with early-stage AD. These research outputs are designed to inform future therapeutic strategies targeting energy metabolism disruption as a mechanism for AD prevention and treatment. The work will be conducted at J. David Gladstone Institutes in San Francisco, California, a non-profit biomedical research organization with established capacity for advanced neuroscience research.Summary of Federal Grant Award
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $801.2k | 2/6/26 |