Project Grant R01AG093756
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a $1.58 million Project Grant on March 15, 2025, under the Aging Research program (CFDA 93.866) to conduct research characterizing microvascular impairment in adults with elevated genetic risk for Alzheimer's disease. The research initiative, which extends through January 31, 2030, investigates the physiological mechanisms through which the apolipoprotein E-epsilon 4 (APOE-E4) allele—the...
- Federal Project Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital a $487,574 Project Grant on May 15, 2025, under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the role of reactive astrocytes in the propagation and clearance of tau pathology in Alzheimer's disease. The project, with a completion date of February 28, 2030, will deliver scientific research outputs aimed at understanding whether glial fibrillary acidic...
- Federal Grant Award Summary The National Institute on Aging awarded Massachusetts General Hospital a $677,276 Project Grant (CFDA 93.866: Aging Research) effective February 15, 2026, through January 31, 2031, to advance positron emission tomography (PET) imaging research of alpha-synuclein pathology in neurodegenerative diseases. The award funds the development and clinical evaluation of [11C]SY08, a novel PET imaging agent that selectively binds fibrillar alpha-synuclein aggregates. The primary...
- Summary of Federal Project Grant Award The National Institute on Aging awarded $129,330 in Project Grant funding to Massachusetts General Hospital (The General Hospital Corporation) under the Aging Research program (CFDA 93.866) for the period June 15, 2025 through March 31, 2030. This award supports research addressing the critical challenge of early detection and accurate diagnosis of Alzheimer's Disease and Related Dementias (ADRD) through development of a machine learning-based prediction...
- Federal Grant Award Summary Massachusetts General Hospital (The General Hospital Corporation) received a $3.17 million Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective February 15, 2026 through February 14, 2030. The award funds development and evaluation of cell therapy approaches to treat Alzheimer's disease by restoring inhibitory neural circuit function. The research focuses on transplanting embryonic mouse medial ganglionic...
- Federal Grant Award Summary Award Details: The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $653,192 Project Grant to The General Hospital Corporation (Massachusetts General Hospital) on July 18, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award extends through June 30, 2030, and supports research conducted at the institution's Charlestown, MA facility. Research Deliverables: This...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital $459,250 under the Aging Research program (CFDA 93.866) on June 1, 2025, for a two-year project extending through May 31, 2027. This project grant supports longitudinal research investigating the mechanisms by which stress and resilience influence cognitive aging and Alzheimer's disease (AD) progression. The research will analyze existing data from two natural history,...
- Federal Project Grant Summary The National Institute on Aging (NIA) awarded Massachusetts General Hospital a Project Grant of $134,726 on February 18, 2026, under the Aging Research program (CFDA 93.866) to support research investigating the biological mechanisms of proteomic aging and frailty prediction. The project, scheduled for completion by January 31, 2028, will deliver three primary research products: (1) identification of causal aging proteins associated with chronic diseases through...
- Federal Grant Award Summary The National Institute on Aging awarded a $441,612 Project Grant to Boston University Medical Campus effective May 15, 2025, under the Aging Research program (CFDA 93.866) to investigate the relationship between modifiable lifestyle risk factors and digital cognitive markers in Alzheimer's disease progression. The research leverages the Framingham Heart Study's multi-generational cohort to develop and validate digital cognitive assessment methods—including digital pen...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus a $636,342 Project Grant effective August 1, 2025, through April 30, 2030, under the Aging Research program (CFDA 93.866). This research initiative supports multiscale modeling and empirical studies examining normal and pathological brain aging, with particular focus on myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the neocortex. The project employs rhesus...
The National Institute on Aging awarded a $684,567 Project Grant to Massachusetts General Hospital (The General Hospital Corporation) for a four-year research initiative beginning March 1, 2026 and concluding December 31, 2029, under the Aging Research program (CFDA 93.866). The grant supports a resubmission methodology study designed to assess the utility of 64Copper-Fibrin-Binding-Probe-8 Positron Emission Tomography (64Cu-FBP8 PET) for in vivo detection and quantification of pathological fibrin in the brain within a multi-biomarker framework. The research leverages the Harvard Aging Brain Study 2 (HABS-2) participant cohort, which includes individuals with varying levels of amyloid and tau pathology, cognitive impairment, and disease status, and incorporates existing amyloid and tau PET imaging data, magnetic resonance imaging, apolipoprotein E genotyping, and cognitive testing results. The research deliverables include evaluation of 64Cu-FBP8 PET pharmacokinetics in cognitively unimpaired and cognitively impaired HABS-2 participants using compartmental modeling approaches, with the primary objective of identifying a simplified, standardized method for routine quantification of brain fibrin load in aging and neurodegeneration. The study directly addresses evidence of fibrin deposition in Alzheimer's disease brain tissue and its co-localization with amyloid pathology, contributing to understanding of vascular damage mechanisms in neurodegenerative disease and informing potential therapeutic targeting strategies in aging populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $684.6k | 2/17/26 |