Project Grant R01AG093475
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $6.42 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) awarded on September 15, 2025, with a completion date of September 14, 2029. This award supports a longitudinal research study investigating how diet composition—specifically Mediterranean versus Western dietary patterns—moderates cognitive aging and neuropathological markers in middle-aged cynomolgus...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $599,623 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with a project completion date of January 31, 2031. This five-year research initiative investigates the synergistic effects of unacylated ghrelin (UNAG) combined with endurance exercise (EE) as an intervention to combat sarcopenia—the progressive loss of muscle mass and...
- Federal Project Grant Award Summary Wake Forest University Health Sciences received a $2.42 million Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 1, 2025, and extending through August 31, 2029. The "Inspiring Healthy Engagement and Learning for Vascular Dementia" (I-HEAL) initiative addresses critical gaps in clinical trial participation for vascular contributions to cognitive impairment and dementia (VCID), with...
- This $342,934.65 project grant from the Department of Health and Human Services National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into acyl chain remodeling and regional lipid dysregulation in Alzheimer's disease. The Trustees of Columbia University in the City of New York, doing business as Health Sciences Division, will analyze lipid composition in brain regions susceptible to Alzheimer's disease, such as the...
- Federal Grant Award Summary Wake Forest University Health Sciences received a $428,410 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective September 20, 2025, through May 31, 2030. The award funds the Research and Education in Alzheimer's Disease and Dementias Initiative for Equity (READDIE) program, designed to facilitate postbaccalaureate trainees' entry into and completion of PhD programs in Alzheimer's disease and related dementias (ADRD)....
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $509,413 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on September 15, 2025, for a project period extending through May 31, 2030. The award supports scientific research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD), specifically examining how m6A (N6-methyladenosine) modifications of messenger RNA control microglial...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $715,801 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) effective June 1, 2025, through March 31, 2030, to conduct research investigating the impact of hypertension and aging on postoperative delirium. The project delivers scientific research services examining the causal mechanisms whereby chronic hypertension contributes to delirium following surgical...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $493,972 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This award funds research on cell type-specific epitranscriptomic regulation in the brain during aging and Alzheimer's disease (AD). The project investigates how adenosine methylation (M6A), the most abundant internal messenger RNA...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $127,224 to the University of California, San Diego on October 24, 2025, under the Aging Research program (CFDA 93.866) to support scientific investigation into the pathological mechanisms of Alzheimer's disease (AD). The project, which extends through August 31, 2028, will elucidate the role of s-nitrosylated phospholipase D3 (SNO-PLD3) in microglial and neuronal pathophysiology associated with AD. Specifically,...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $286,000 Project Grant to the University of Oklahoma Health Sciences Center on September 15, 2025, under the Aging Research program (CFDA 93.866) to support research on microvascular endothelial lipid metabolism and age-related vascular cognitive impairment. The research deliverable involves a novel pilot study examining how dysregulated lipid metabolism in brain endothelial cells contributes to cognitive decline...
Wake Forest University Health Sciences received a $668,290 Project Grant award from the National Institute on Aging (Aging Research program, CFDA 93.866) effective February 15, 2026, through January 31, 2031, to conduct research on the metabolism and protective role of docosahexaenoic acid (DHA), an essential omega-3 nutrient. The research addresses a critical gap in understanding DHA metabolism regulation in pre- and post-disease states, with particular focus on the enzyme long-chain acyl-CoA synthetase 6 (ACSL6) and its role in neurological health. The project will utilize a novel preclinical model featuring a ~50% deficit in DHA specifically in neurons to mechanistically test how DHA metabolism impacts health outcomes. The deliverables encompass three primary research aims: determining the role of DHA metabolism in neurological health (Aim 1); deriving the regulatory mechanisms that control neural DHA accrual and turnover (Aim 2); and testing the hypothesis that DHA-lipid mediators in membrane-bound states serve as readily available protective agents (Aim 3). This work is designed to overcome long-standing limitations in the field by providing fundamental breakthroughs regarding DHA metabolism's importance in health and disease prevention, with potential therapeutic implications for treating age-related neurological conditions in populations where an estimated 80% of the U.S. population is nutritionally deficient in DHA.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $668.3k | 2/6/26 |