Project Grant R01AG093283
- Federal Grant Award Summary The Salk Institute for Biological Studies received a $785,348 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded on August 15, 2025, with completion targeted for July 31, 2027. This award funds fundamental research investigating the mechanistic relationship between chronic sleep disruption (CSD) and biological aging processes. The research addresses a significant public health concern, as CSD is...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a $1,459,072 Project Grant on August 1, 2025, under the Aging Research program (CFDA 93.866) to investigate inhibitory neuron dysfunction in Alzheimer's disease (AD). The research will develop and implement innovative methodologies to monitor and manipulate two distinct inhibitory interneuron cell populations—parvalbumin (PVALB) and somatostatin (SST) cells—in both wildtype and AD-knock-in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Scripps Research Institute a $506,000 project grant under the Aging Research program (CFDA 93.866) beginning August 15, 2025, with completion scheduled for July 31, 2027. The award funds research focused on engineering synthetic biomolecular condensates (BMCs) to enable targeted autophagy modulation, a promising therapeutic target for age-related diseases. The primary deliverable is development of an advanced...
- Federal Grant Award Summary The National Institute on Aging awarded a $1.47M Project Grant to Stanford University effective January 15, 2026, through November 30, 2030, under the Aging Research program (CFDA 93.866). This multi-investigator research initiative will conduct comprehensive, systems-level studies to understand how the brain functions as a "neural pacemaker" in regulating organismal aging. The research leverages the killifish model organism—a vertebrate with a naturally...
- Federal Project Grant Award Summary The National Institute on Aging (NIA), through its Aging Research program (CFDA 93.866), awarded $528,000 to the Van Andel Research Institute (VAI) beginning September 15, 2025, with completion targeted for August 31, 2027. This project grant supports the development and application of advanced single-cell whole-genome bisulfite sequencing technology combined with lineage-tracing methodologies to analyze epigenetic clocks at the single-cell level. The research...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded University of Maryland, Baltimore a $649,766 Project Grant effective March 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This research grant funds a comprehensive five-year investigation examining how hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels mediate olfactory dysfunction in aging and Alzheimer's disease. The project delivers scientific research...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded J. David Gladstone Institutes a Project Grant totaling $804,450 (awarded June 1, 2025, with completion targeted for March 31, 2030) under the Aging Research program (CFDA 93.866) to conduct biomedical research investigating the molecular mechanisms underlying Apolipoprotein E4 (APOE4)-driven pathogenesis in Alzheimer's disease (AD). The research will focus on targeting the growth factor protein NELL2 (Neural...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $127,224 to the University of California, San Diego on October 24, 2025, under the Aging Research program (CFDA 93.866) to support scientific investigation into the pathological mechanisms of Alzheimer's disease (AD). The project, which extends through August 31, 2028, will elucidate the role of s-nitrosylated phospholipase D3 (SNO-PLD3) in microglial and neuronal pathophysiology associated with AD. Specifically,...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded Boston University Medical Campus a $636,342 Project Grant effective August 1, 2025, through April 30, 2030, under the Aging Research program (CFDA 93.866). This research initiative supports multiscale modeling and empirical studies examining normal and pathological brain aging, with particular focus on myelin dystrophy, synaptic loss, and neuronal hyperexcitability in the neocortex. The project employs rhesus...
- Federal Grant Award Summary J. David Gladstone Institutes received a Project Grant award of $817,357 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective June 15, 2025, with a completion date of March 31, 2030. The award supports research applying novel machine learning (ML) approaches to behavioral analysis and brain signal integration in humanized Alzheimer's disease (AD) models. The primary deliverable involves validation and development of a...
The National Institute on Aging (NIA) awarded The Salk Institute for Biological Studies a Project Grant of $620,441 under the Aging Research program (CFDA 93.866) on February 15, 2026, with a project completion date of January 31, 2031. This research grant supports a comprehensive scientific investigation into activity-dependent cell survival mechanisms in the adult somatosensory dorsal horn, with direct implications for understanding sensorimotor behavioral changes during the aging process. The project will deliver research deliverables including characterization of molecular and cellular changes within spinal dorsal horn neuronal populations as animals age, identification of specific cutaneous afferent inputs that support neuronal cell survival in adult mice, and functional analysis of how dorsal horn remodeling affects sensorimotor behaviors in aging subjects. The research employs advanced transcriptomic and intersectional genetic tools to investigate how loss of touch sensation and mechanosensory end organs (such as Merkel cells) during aging leads to age-related neuronal cell loss by apoptosis in the dorsal horn. Key project objectives include selectively perturbing activity in different classes of cutaneous afferent neurons, identifying molecularly defined dorsal horn populations maintained by peripheral input, and determining the functional consequences of dorsal horn cellular composition changes for motor and sensory behaviors. This research directly supports the NIA's mission to advance understanding of the aging process and age-related neurological changes through rigorous biomedical investigation.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $620.4k | 2/5/26 |