Project Grant R01AG092720
- Federal Grant Award Summary Emory University received a $657,222 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) awarded February 15, 2026, with a completion date of January 31, 2031. The grant supports research investigating the pathological mechanisms of amyloid-beta (Aβ) protein interactions in Alzheimer's disease (AD). The project will deliver scientific findings through three primary research objectives: determining the molar abundance...
- Federal Project Grant Award Summary Emory University received a $528,876 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 1, 2025 through March 31, 2030. This award supports the development and application of novel analytical tools to investigate cis- and trans-genetic regulation of brain transcriptomics and proteomics associated with Alzheimer's disease and related dementias (AD/ADRD). The research extends current...
- Federal Grant Award Summary Emory University received a $2.27 million Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) effective May 15, 2025, with completion targeted for January 31, 2030. The award funds the development of a novel positron emission tomography (PET) ligand targeting poly(ADP-ribose) polymerase-1 (PARP1) for imaging in Alzheimer's disease and related dementias. The primary deliverable is a brain-penetrant, PARP1-selective...
- Federal Project Grant Award Summary Emory University received a $147,656 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), with an award date of March 11, 2025 and project completion date of September 29, 2025. The grant supports the development of the first human locus coeruleus (LC) organoid model to advance understanding of Alzheimer's disease (AD) pathology. The research addresses a critical gap in AD knowledge by utilizing...
- Federal Project Grant Award Summary Duke University's Office of Research Administration was awarded $509,413 by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on September 15, 2025, for a project period extending through May 31, 2030. The award supports scientific research investigating epitranscriptomic regulation of microglia in Alzheimer's disease (AD), specifically examining how m6A (N6-methyladenosine) modifications of messenger RNA control microglial...
- Federal Grant Award Summary Award Overview: Emory University received a $3.25 million Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 1, 2025, with a completion date of August 31, 2029. The research is being conducted at Emory's Atlanta, Georgia campus through the Office of Sponsored Programs Division. Research Objectives and Deliverables: This project investigates how indole and indole derivatives produced by commensal...
- Federal Project Grant Award Summary Augusta University Research Institute, Inc. (AURI), doing business as Georgia Health Sciences, received a $542,699 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2030. The award supports biomedical research investigating epigenetic mechanisms underlying the selective vulnerability of parvalbumin-positive neurons in the entorhinal cortex during aging and...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $493,972 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective January 1, 2026 through December 31, 2030. This award funds research on cell type-specific epitranscriptomic regulation in the brain during aging and Alzheimer's disease (AD). The project investigates how adenosine methylation (M6A), the most abundant internal messenger RNA...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded $127,224 to the University of California, San Diego on October 24, 2025, under the Aging Research program (CFDA 93.866) to support scientific investigation into the pathological mechanisms of Alzheimer's disease (AD). The project, which extends through August 31, 2028, will elucidate the role of s-nitrosylated phospholipase D3 (SNO-PLD3) in microglial and neuronal pathophysiology associated with AD. Specifically,...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded $852,273 to The Trustees of Columbia University in the City of New York, Health Sciences Division, through the Aging Research program (CFDA 93.866) on September 1, 2025, for a project extending through May 31, 2030. This Project Grant funds a comprehensive genetic mapping study investigating the role of RNA modifications—specifically N6-methyladenosine (M6A) and pseudouridine (Ps)—in Alzheimer's disease (AD) pathogenesis...
Emory University received a $651,466 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866) beginning February 15, 2026 and extending through November 30, 2030. The award supports biomedical research investigating the role of promyelocytic leukemia protein (PML) in oxidative stress and Alzheimer's disease pathogenesis. The research focuses on understanding how PML regulates microRNA (miRNA) biogenesis through the microprocessor complex—specifically the interaction between the nuclear RNase III enzyme DROSHA and its co-factor DGCR8—and how dysregulation of this pathway contributes to neurodegeneration in Alzheimer's disease. The funded research will advance scientific understanding of the molecular mechanisms underlying Alzheimer's disease by examining a newly identified PML-dependent mechanism that modulates microprocessor activity and miRNA generation. Specifically, the project proposes investigation of a "sumoylated super active microprocessor" concept to elucidate how PML functions as a SUMO (small ubiquitin-like modifier) E3 enzyme in response to oxidative stress and neurodegeneration. The work will be conducted at Emory University's Atlanta, Georgia location and aligns with the National Institute on Aging's mission to support research directed toward greater understanding of age-related diseases and identification of prevention and treatment approaches for Alzheimer's disease and related dementias.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $651.5k | 2/3/26 |