Project Grant R01AG092711
- Federal Project Grant Summary Cedars-Sinai Medical Center received a $2,591,620 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period September 15, 2025, through August 31, 2029. The award funds research to determine the role of hypothalamic neurons in age-related physiological decline, with particular focus on how arginine-vasopressin (AVP) transcription in supraoptic hypothalamic neurons contributes to vulnerability in older...
- Federal Grant Award Summary Cedars-Sinai Medical Center received a $419,321 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded on September 15, 2025, with a completion date of August 31, 2027. This proof-of-concept study will investigate neurocognitive dysfunction in patients with adrenal cortisol insufficiency (ACI), a rare metabolic disease that impairs cognitive function despite standard hydrocortisone treatment. The research will...
- Federal Grant Award Summary Cedars-Sinai Medical Center received a $701,073 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) on February 15, 2026, with completion scheduled for December 31, 2030. The grant funds a time-sensitive prospective cohort study examining the neurological health effects of wildfire exposure among individuals affected by the January 2025 Los Angeles wildfires. The research will track newly appearing or...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $124,875 Project Grant to Cedars-Sinai Medical Center, effective September 4, 2025, through May 31, 2030, under the Aging Research program (CFDA 93.866). This career development award supports research investigating the role of senescent cells in the heightened susceptibility of elderly and chronically ill patients to infectious diseases. The project, led by Dr. Larissa Langhi Prata, an Assistant Professor of...
- Federal Grant Award Summary The National Institute on Aging awarded a Project Grant of $126,684.00 to the University of California, Los Angeles under the Aging Research program (CFDA 93.866) on March 18, 2026, with completion targeted for September 25, 2027. This award funds basic biomedical research to elucidate the signaling mechanisms by which estrogen regulates metabolic responses to energy deficit, with direct application to understanding metabolic changes occurring during menopause. The...
- Federal Grant Award Summary The National Institutes of Health (NIH) Office of the Director awarded $863,500 to the University of California, Irvine under the Trans-NIH Research Support program (CFDA 93.310) on September 18, 2025, for a project grant focused on developing anti-fibrogenic therapy to address aging-associated urethral dysfunction in women. The award supports investigator-initiated research through August 31, 2027, and funds basic science research investigating the mechanisms by...
- Federal Project Grant Award Summary The National Institute on Aging awarded a $3.43 million Project Grant under the Aging Research program (CFDA 93.866) to the University of California, San Francisco, effective September 15, 2025, through August 31, 2029. This grant supports comprehensive research investigating biological drivers of sex differences in frontotemporal dementia (FTD), the leading cause of young-onset dementia. The research addresses a significant knowledge gap by examining why...
- Federal Cooperative Agreement Summary Cedars-Sinai Medical Center received a $2.25 million Cooperative Agreement from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 15, 2025, through August 31, 2030. Under the Microvascular Aging Effects – Women's Evaluation of Systemic Aging Tenacity in Heart, Brain and Frailty (MAE-WEST HBF) Specialized Center of Research Excellence (SCORE) initiative, Principal...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded a $2.7 million Project Grant to the University of California, Los Angeles (UCLA) under the Aging Research program (CFDA 93.866) to conduct a four-year comparative outcomes study examining post-acute care discharge destinations for older patients with Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). The research will utilize Veterans Affairs electronic health record data from approximately 100 VA...
- Federal Grant Award Summary The National Institutes of Health Office of the Director awarded a $458,616 Project Grant to the University of Texas at Dallas on September 15, 2025, under the Trans-NIH Research Support program (CFDA 93.310) for research titled "The Impact of Estrogen Hormone Therapy Modality on Urobiome Dynamics in Postmenopausal Women." The project, scheduled for completion by August 31, 2027, will investigate why estrogen hormone therapy (EHT) reduces recurrent urinary...
Cedars-Sinai Medical Center received a $717,957 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective March 1, 2026, through February 28, 2031. This five-year research initiative investigates estrogen signaling mechanisms in urinary tract infection (UTI)-related delirium, with focus on postmenopausal women disproportionately affected by this condition. The research deliverables include determination of neuroprotective molecular mechanisms of 17β-estradiol (E2) through estrogen receptor knockout strain studies, evaluation of bazedoxifene as a novel pharmacological treatment targeting E2 signaling and interleukin-6 trans-signaling pathways, and assessment of exercise as an environmental modifier of E2 signaling to prevent UTI-induced delirium. The project directly addresses a significant public health burden, as delirium affects tens of millions annually with associated healthcare costs exceeding $152 billion per year in the United States. Research outcomes will provide scientific evidence supporting potential therapeutic interventions for reducing delirium incidence in postmenopausal women with and without Alzheimer's disease and related dementias, contributing to the NIA's mission of advancing prevention and treatment strategies for age-related conditions.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $16.1k | 2/19/26 | ||
| Not listed | $701.9k | 2/9/26 |