Project Grant R01AG091461
- The National Institute on Aging awarded New York University $712,578 on February 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a prospective study identifying viral infections associated with cognition decline and Alzheimer's disease risk across three prospective cohorts. The award supports comprehensive serologic profiling using VirScan, a bacteriophage immunoprecipitation sequencing technology, to detect immune responses to human viruses and analyze antiviral antibodies in...
- The National Institute on Aging awarded Icahn School of Medicine at Mount Sinai $746,063 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate amyloid beta plaque formation and neuroinflammation in aging people with HIV. The award funds exploration of cell-specific transcriptional changes associated with early amyloid beta deposition in human brain, distinguishing compacted amyloid with early neuritic pathology from diffuse amyloid without neuritic change, and...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $511,574 on July 1, 2026, under the Aging Research program (CFDA 93.866) to develop statistical methods for precision health management in high-risk Alzheimer's disease populations. The recipient will conduct three integrated research activities. Aim 1 involves evidence synthesis through semi-automated systematic review and meta-analyses of published studies to synthesize evidence on prognostic...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $735,598 on July 15, 2026, under the Aging Research program (CFDA 93.866) to enhance research capacity for addressing Alzheimer's disease and related dementias and metal-induced cognitive decline in an aging cohort in Bangladesh. The award funds research investigating how chronic exposure to neurotoxic metal mixtures—including arsenic, lead, cadmium, manganese, and copper—influences cognitive...
- The National Institute on Aging awarded New York University $6.203 million on September 15, 2025, under the Aging Research program (CFDA 93.866) to examine peripheral immune markers and vascular dysfunction as contributors to cognitive decline and Alzheimer's disease. The research integrates circulating biomarkers—platelet aggregation, neutrophil activity, and proteomic data—with advanced imaging to assess associations between vascular and immune dysfunction and cerebrovascular burden, amyloid...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $392,543 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate genetic regulators of microglial NF-kappa-B signaling in Alzheimer's disease. The award funds research into how genetic protective and risk factors for Alzheimer's disease regulate human microglial pro-inflammatory responses to oligomeric amyloid-beta. The project examines the genetic modifier SH3RF3,...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $529,744 on February 15, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of entorhinal cortex hyperactivity, neuroinflammation, and tau pathology progression in Alzheimer's disease. The research will use two-photon microscopy and chemogenetic manipulation to test three central hypotheses: that entorhinal cortex layer 2 neuronal hyperactivity drives disease...
- The National Institute on Aging awarded The University of Chicago $1,460,509 on July 1, 2026, under the Aging Research program (CFDA 93.866) to conduct a longitudinal study examining how environmental exposures contribute to Alzheimer's disease and related dementias among older US adults. The project, titled "Experiences, Exposures, and Alzheimer's Disease: Longitudinal Study of Olfaction, Cognition, and Metabolism in Older US Adults (NSHAP Exposome)," will enrich data collection...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $100,228 on February 18, 2027, under the Aging Research program (CFDA 93.866) for epigenetic regulation research on microglial dysfunction in Alzheimer's disease. The award funds laboratory research investigating how the protein ARID5B regulates histone modifications that influence microglial identity and function in Alzheimer's disease pathogenesis. The recipient will use CRISPR/Cas9 and CRISPR...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded $132,300 to The Trustees of Columbia University in the City of New York on July 15, 2026, under the Aging Research program (CFDA 93.866) to examine the relationship between job loss due to layoffs across working years and the risk of Alzheimer's disease and related dementias in mid-to-later life. The research leverages longitudinal data from three complementary datasets spanning the working years of the...
The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $705,594 on September 1, 2026, under the Aging Research program (CFDA 93.866) to investigate how pathogen exposure history and chronic latent infections influence Alzheimer's disease and related dementias risk across two distinct human populations. The project examines infection burden and its relationship to Alzheimer's disease biomarkers and cognitive decline by integrating existing longitudinal cognitive and brain imaging data from two cohorts with contrasting pathogen exposure: the Tsimane Health and Life History Project, studying an indigenous subsistence population in the Bolivian Amazon with high pathogen exposure including helminth prevalence, and the Berlin Aging Study-II, studying mostly older adults in and around Berlin. The research supplements existing cohort data with state-of-the-art blood biomarkers of Alzheimer's disease and emerging pathogenomics technology (VirScan) to simultaneously quantify antibodies to tens of thousands of viral proteins from thousands of viral strains as well as non-viral pathogens. The three primary aims assess overall and chronic infection burden and specific pathogen prevalence across both cohorts, evaluate whether infection histories predict current levels of Alzheimer's disease biomarkers, and assess whether infection exposure predicts cognitive trajectories and brain volume changes. Performance occurs in New York, New York. The award period extends from September 1, 2026, through July 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $705.6k | 9/1/26 |