Project Grant K99AG100795
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $511,574 on July 1, 2026, under the Aging Research program (CFDA 93.866) to develop statistical methods for precision health management in high-risk Alzheimer's disease populations. The recipient will conduct three integrated research activities. Aim 1 involves evidence synthesis through semi-automated systematic review and meta-analyses of published studies to synthesize evidence on prognostic...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $735,598 on July 15, 2026, under the Aging Research program (CFDA 93.866) to enhance research capacity for addressing Alzheimer's disease and related dementias and metal-induced cognitive decline in an aging cohort in Bangladesh. The award funds research investigating how chronic exposure to neurotoxic metal mixtures—including arsenic, lead, cadmium, manganese, and copper—influences cognitive...
- The National Institute on Aging awarded Albert Einstein College of Medicine $134,044 under the Aging Research program (CFDA 93.866) on July 1, 2026, to establish a program in life-course epidemiology of Alzheimer's disease and related dementias (ADRD) with emphasis on prevention and early intervention. The award funds development of a national resource and research training program centered on understanding modifiable ADRD risk factors across the lifespan, addressing a critical gap in Einstein's...
- The National Institute on Aging awarded New York University $137,245 on July 15, 2026, under the Aging Research program (CFDA 93.866) to explore the relationship between obesity and dementia or Alzheimer's disease in older patients with end-stage kidney disease. The recipient will examine whether body mass index, augmented with novel anthropometric and body composition measures, associates with cognitive decline and dementia diagnosis in this population, and investigate whether intentional...
- The National Institute on Aging, part of the Department of Health and Human Services National Institutes of Health, awarded $249,000 to The Regents of The University of Colorado on July 1, 2026, under the Aging Research program (CFDA 93.866). The award funds research investigating how beta-amyloid accumulation impacts hypocretin neuron activity and subsequently disrupts sleep architecture in Alzheimer's disease. The research examines whether beta-amyloid accelerates death of hypocretin neurons...
- The National Institute on Aging, part of the Department of Health and Human Services, awarded the University of California, Los Angeles $146,750 under the Aging Research program (CFDA 93.866) on July 1, 2026, to identify molecular-neuropathological signatures in Alzheimer's disease, frontotemporal lobar degeneration, and long COVID. The recipient will employ single-cell spatial multi-omics on postmortem brain tissues to characterize molecular and cellular alterations linked to selective...
- The National Institute on Aging awarded the University of California, Los Angeles $623,176 on September 1, 2026, under the Aging Research program (CFDA 93.866) to conduct research on modifiable risk factors for Alzheimer's disease and related dementias among individuals aged 90 and older. The research triangulates evidence across four data sources—the LifeAfter90 Study (1,397 participants, all aged 90), the 90+ Study (1,630 participants, all aged 90), the Health and Retirement Study (3,359...
- The National Institute on Aging, a component of the Department of Health and Human Services National Institutes of Health, awarded $198,728 to The Rockefeller University on February 21, 2026, under the Aging Research program (CFDA 93.866) to identify cell type-specific RNA expression and regulatory changes in entorhinal cortex clinical samples of Alzheimer's disease. The funded work develops and applies a novel methodology called CLIP-FANS (crosslinking immunoprecipitation-fluorescence activated...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $100,228 on February 18, 2027, under the Aging Research program (CFDA 93.866) for epigenetic regulation research on microglial dysfunction in Alzheimer's disease. The award funds laboratory research investigating how the protein ARID5B regulates histone modifications that influence microglial identity and function in Alzheimer's disease pathogenesis. The recipient will use CRISPR/Cas9 and CRISPR...
- The National Institute on Aging awarded The Trustees of Columbia University in the City of New York $452,375 on January 1, 2026, under the Aging Research program (CFDA 93.866) to investigate the role of semaphorin 3A in microglial activation and Alzheimer's disease pathology. The research will determine the functional role and mechanistic basis for semaphorin 3A–mediated regulation of microglial activation in Alzheimer's disease. Building on preliminary findings using human induced pluripotent...
The National Institute on Aging, part of the Department of Health and Human Services, awarded $132,300 to The Trustees of Columbia University in the City of New York on July 15, 2026, under the Aging Research program (CFDA 93.866) to examine the relationship between job loss due to layoffs across working years and the risk of Alzheimer's disease and related dementias in mid-to-later life. The research leverages longitudinal data from three complementary datasets spanning the working years of the life course: the National Longitudinal Survey of Youth 1979, the Health and Retirement Study, and the Washington Heights and Inwood Columbia Aging Project. The study examines overall relationships between layoffs and cognitive decline and dementia risk, investigates impacts among at-risk subgroups, and explores underlying cardiovascular and neuropathological pathways. The project is structured as a K99/R00 award, combining mentored research and independent research phases. The award period runs from July 15, 2026 through June 30, 2028. Work is performed in New York, New York. This is a Project Grant, a standard assistance type under the NIA's Aging Research program, which supports biomedical, social, and behavioral research directed toward understanding aging processes and age-related diseases, with particular emphasis on Alzheimer's disease prevention and treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $132.3k | 8/26/26 |