Project Grant R01AG090551
Award Date
1/1/25
Completion Date
12/31/29
Dollars Obligated
$757K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98195, USA
Similar Awards
The federal Project Grant award R01NS136684, provided by the National Institute on Aging (CFDA Program 93.866 - Aging Research), supports biophysical and pathophysiological studies of the interaction between the proteins TDP-43 and tau. The total funding amount is $562,241.00, with the award date of May 17, 2024 and an ultimate completion date of April 30, 2029.
The key products and services being delivered under this grant include:
Collaborative research between the University of Florida...
This $603,031 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Northwestern University supports a 1-year research study on the clinical, cellular, and pathological features of comorbid Alzheimer's disease and TDP-43 proteinopathies in elderly patients with amnestic dementia. The key objectives are to: 1) identify the shared versus distinct clinical, neuropsychological, and psychiatric characteristics of this condition; 2) determine the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $159,362 to the University of Washington to investigate the role of the endoplasmic reticulum unfolded protein response in tauopathy. The research aims to 1) identify UPR-related genes that enhance tau-related phenotypes by monitoring tau turnover, and 2) determine the role of UPR activation in TDP-43 cleavage and localization relative to tau. The project will leverage genetic approaches in...
This $1,823,353 Project Grant awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to the Seattle Institute For Biomedical And Clinical Research aims to elucidate the molecular mechanisms by which pathological tau protein causes neurodegeneration in Alzheimer's disease (AD) and related tauopathy disorders.
The research project will leverage a C. elegans model of tauopathy to investigate the functional role of nuclear speckles, membraneless organelles involved in RNA...
This $623,631 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the Seattle Institute for Biomedical and Clinical Research to investigate how the SUT-6/NIPP1 protein regulates pathological tau in Alzheimer's disease and other neurodegenerative "tauopathy" disorders. The 5-year project aims to: 1) Define the functions of SUT-6/NIPP1 important for suppressing tau toxicity using a C. elegans model, 2) Identify neuronal...
This $2,061,909 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to identify molecular mechanisms regulating tau protein aggregation and neurodegeneration in tauopathies, including Alzheimer's disease. The study aims to characterize the opposing effects of two chaperone protein complexes - the "foldase" complex that stabilizes tau, and the "degradase" complex that targets tau for degradation. The research will be...
This $320,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the impact of tau protein misfolding on alternative polyadenylation (APA) regulation in Alzheimer's disease (AD). The primary objectives are to:
Identify and compare mRNA isoform libraries from mouse primary hippocampal neurons expressing wild-type and pathogenic mutant tau proteins using the Poly(A)-ClickSeq (PAC-Seq) technology.
Determine how tau...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $772,621 to the University of North Carolina at Chapel Hill to conduct research on environmental risk factors linked to TDP-43 proteinopathies, which are associated with frontotemporal dementia, amyotrophic lateral sclerosis, and Alzheimer's disease. The 5-year project aims to systematically identify environmental toxicants that promote TDP-43 dysfunction and neurodegeneration, and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $211,875 to New York University School of Medicine to conduct research on the disruption of endosomal microautophagy by pathological tau protein. The research aims to elucidate the role of pathological tau in destabilizing endosomal microautophagy, a crucial protein degradation pathway, and assess the impact on neuronal function and tau aggregate spreading in Alzheimer's disease. Key...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Wayne State University provides $385,000 over 5 years to investigate how pathogenic forms of the tau protein interfere with dendritic protein synthesis and contribute to synaptic dysfunction in Alzheimer's disease. The researchers will leverage a novel suite of molecular tools to study this process in a tau pathology mouse model, with the goal of providing insights into potential intervention...