Project Grant R01AG090356
- The National Institute on Aging (NIA) awarded a $639,997 Project Grant under the Aging Research federal grant program (CFDA 93.866) to The Spaulding Rehabilitation Hospital Corporation in Massachusetts on May 15, 2025. The grant supports a research project titled "Mechano-Regulation of Circulating Extracellular Vesicle Cargoes to Enhance Knee Joint Health" with a planned completion date of March 31, 2030. The project aims to investigate how physiological exercise regulates molecular...
- This $109,076 project grant, awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) on November 27, 2025, aims to investigate the impact of modulating synovial mechanobiology to mitigate disease progression in osteoarthritis (OA). The project will evaluate the effect of genetic and pharmacologic suppression of non-muscle myosin II (NM-II) on fibroblast-like synoviocyte (FLS) activation, synovial fibrosis, and OA pathogenesis using in vitro and in vivo models. The research is...
- This Project Grant award of $673,012 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to understand the neuromechanical bases for the increased energy cost of walking in aging. The University of Massachusetts is the primary awardee, with the goal of determining how age-related changes in gait strategy combine with muscle weaknesses to increase the energy cost of walking in older adults. The research will address key knowledge gaps regarding relative...
- This $426,250 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Regents of the University of Minnesota aims to develop an exosome-based therapy for the treatment of osteoarthritis (OA). The project will leverage the immunoregulatory mechanisms present during fetal development to identify multi-tissue organoid-derived exosomes with anti-inflammatory and chondrocyte proliferation potential. Key activities include in vitro studies using human PBMCs to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $245,434 to Wake Forest University Health Sciences to conduct research on preserving muscle and bone health in older adults undergoing weight loss interventions. The 2.5-year project aims to develop automated analysis techniques to measure changes in muscle quantity and quality, as well as bone strength, using computed tomography (CT) scans collected as part of an ongoing clinical trial....
- This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to define the systemic mechanisms by which adipose (fat) tissue communicates with the knee joint to drive the development of osteoarthritis (OA). The $1,476,001 award to the Regents of the University of California, San Francisco will fund a comprehensive investigation of three potential interorgan crosstalk pathways: signaling through...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $452,437 to Tufts University School of Medicine to investigate the role of mast cell heterogeneity in the pathogenesis of osteoarthritis (OA). The objective is to uncover the genetic basis and functions of different mast cell subtypes in the OA synovium using advanced proteomics and single-cell RNA sequencing technologies, as well as testing them in a mouse model. The research aims to...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,126,515 to Trustees of Indiana University in Indianapolis, IN to conduct research aimed at understanding how the L-BAIBA/FGF23 axis, an interaction between muscle and bone, can be targeted to enhance musculoskeletal health and resilience in aging populations. The research seeks to elucidate the mechanisms by which this muscle-bone signaling pathway becomes dysregulated with age, leading to...
- This federal Project Grant award of $451,000.00 from the National Institute on Aging (CFDA 93.866 Aging Research) supports a research project titled "Estrogen Modulation of Chondrocyte Mechanotransduction via Piezo1 and TRPV4." The project aims to investigate how biological sex and sex hormones, particularly estrogen, modulate the response of chondrocytes (cartilage cells) to mechanical stimulation through the mechanosensitive channels Piezo1 and TRPV4. This research seeks to better...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
This $665,970 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate how mechanical loading protocols, such as exercise and nutrition, can regulate knee joint health and potentially ameliorate age-related knee osteoarthritis. The award will fund a 5-year research project conducted by an interdisciplinary team at The Spaulding Rehabilitation Hospital Corporation in Massachusetts. The project aims to use innovative approaches, including a menopausal mouse model and network medicine techniques, to elucidate the molecular mechanisms underlying the disease-modifying impacts of exercise, both alone and in combination with nutritional interventions. The goal is to provide mechanistic insights that can inform the development of new rehabilitation programs and disease-modifying therapies for this major public health burden affecting over 30 million Americans.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $34.4k | 8/7/25 | ||
| Not listed | $631.5k | 7/29/25 |