The National Institute on Aging (NIA) awarded a $639,997 Project Grant (CFDA 93.866 - Aging Research) to The Spaulding Rehabilitation Hospital Corporation to investigate how exercise regulates molecular circuitry in cartilage and the knee joint to promote cartilage integrity and joint health in the context of knee osteoarthritis. The 5-year project aims to provide mechanistic insights into how molecular cargoes in circulating extracellular vesicles impact osteoarthritic knee joint health in a...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $452,437 to Tufts University School of Medicine to investigate the role of mast cell heterogeneity in the pathogenesis of osteoarthritis (OA). The objective is to uncover the genetic basis and functions of different mast cell subtypes in the OA synovium using advanced proteomics and single-cell RNA sequencing technologies, as well as testing them in a mouse model. The research aims to...
This Project Grant award of $734,778 from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) will support the development of a novel, scalable, allogeneic cell platform based on human induced pluripotent stem cell (iPSC)-derived chimeric antigen receptor (CAR) macrophages. The primary goals are to evaluate CAR designs for targeting pathogenic tau protein and to incorporate genetic modifications to mitigate inflammatory responses, in order to address both...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $123,040 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to investigate the therapeutic role of the NFAT1 transcription factor in osteoarthritis. The 5-year project, which began on August 1, 2024, aims to evaluate the potential of AAV-delivered NFAT1 gene therapy in treating...
This Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) aims to define the systemic mechanisms by which adipose (fat) tissue communicates with the knee joint to drive the development of osteoarthritis (OA). The $1,476,001 award to the Regents of the University of California, San Francisco will fund a comprehensive investigation of three potential interorgan crosstalk pathways: signaling through...
This federal Project Grant award of $513,740.00 was provided by the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), to develop a novel exosome-based nano-scavenger (EBNS) for the targeted removal of amyloid-beta (Aβ) proteins associated with Alzheimer's disease (AD) and other amyloid-related disorders. The 3-year project aims to: 1) genetically engineer exosomes to load Aβ-targeting antibodies and Aβ-degrading enzymes; 2) establish isolation and...
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) awarded a $361,300 Project Grant under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846) to the University of North Carolina at Chapel Hill. The goal of this 2-year exploratory/developmental project is to use high-throughput small molecule screening and CRISPR screening technologies to identify signaling pathways and therapeutic targets for disease modification in osteoarthritis...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $649,679 to the Regents of the University of Minnesota to conduct research on mechanisms of aging. The project aims to evaluate how a population of mouse T cells can be iteratively boosted and passaged among young mice for over 11 years, exceeding the normal mouse lifespan, while retaining functional competence and proliferative potential. The research will investigate factors such as...
This Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $456,808 to the Buck Institute for Research on Aging to develop innovative mass spectrometry imaging (MSI) technologies and perform deep proteomic profiling of bone tissues. The goal is to spatially visualize changes in the extracellular matrix and glycans related to osteoarthritis,...
This Project Grant award of $578,275.00 from the National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports research by The Spaulding Rehabilitation Hospital Corporation in Charlestown, MA to investigate sex and age-related differences in the development of knee osteoarthritis. The research aims to mechanistically interrogate the direct role of soluble microenvironmental factors and extracellular matrix stiffening on the loss of cartilage integrity, using...