Project Grant R01AG090302

Award Date 12/15/24
Completion Date 11/30/29
Dollars Obligated $699K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Boston, MA 02114, USA
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This Project Grant award, valued at $134,730.00, was issued by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The goal of this project is to develop electroencephalogram (EEG) biomarkers to predict the future risk of dementia and monitor cognitive decline in older adults. The research will leverage existing datasets from the National Sleep Research...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158 to Synaptic Health LLC to develop a novel closed-loop feedback neuromodulation system for improving slow wave sleep in Alzheimer's disease patients. The goal is to create a prototype device that can sense sleep architecture and provide peripheral neuromodulation stimulation to individuals over 65, a high-risk group for Alzheimer's disease. The successful completion of this Phase I...
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This Project Grant award from the National Institute on Aging (Federal Grant Program CFDA 93.866 - Aging Research) totaling $698,870.00 will support research to investigate the effects of thalamic stimulation on sleep oscillations in humans. The key products and services to be delivered under this award include:

  1. Studying the spatial extent of thalamic stimulation-evoked spindles and the disruption of spindles through real-time closed-loop stimulation in 50 patients with medication-refractory epilepsy. This will provide direct evidence on how thalamic stimulation affects sleep oscillations.

  2. Evaluating the impact of therapeutic thalamic stimulation on sleep oscillations and integrity in 25 patients with chronically implanted thalamic stimulators for epilepsy control. This will assess whether thalamic stimulation evokes spindles and causes micro-arousals during sleep.

The research will be conducted through a collaboration between the lead organization, The General Hospital Corporation (Massachusetts General Hospital), and a sub-awardee, Brigham & Women's Hospital, which will provide surgical and data analysis expertise. The award has a start date of December 15, 2024, and an ultimate completion date of November 30, 2029.

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