This Project Grant award, valued at $134,730.00, was issued by the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The goal of this project is to develop electroencephalogram (EEG) biomarkers to predict the future risk of dementia and monitor cognitive decline in older adults. The research will leverage existing datasets from the National Sleep Research...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158 to Synaptic Health LLC to develop a novel closed-loop feedback neuromodulation system for improving slow wave sleep in Alzheimer's disease patients. The goal is to create a prototype device that can sense sleep architecture and provide peripheral neuromodulation stimulation to individuals over 65, a high-risk group for Alzheimer's disease. The successful completion of this Phase I...
The National Institute on Aging (NIA) awarded Brigham & Women's Hospital Inc. a $2,576,936 Project Grant under the Aging Research federal grant program (CFDA 93.866) to characterize the variability in sleep spindle activity across a population and evaluate the use of sleep spindle dynamics as biomarkers for Alzheimer's disease, mild cognitive impairment, and trisomy 21. The 3-year project will develop statistical models and methods to analyze sleep spindle patterns and their relationship...
This federal Project Grant award, worth $537,000.00, was granted by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866). The award aims to leverage social networks to improve sleep and mindfulness among cognitively unimpaired older adults (age 55+) residing in low-income housing in Boston. The key objectives are to: 1) culturally adapt the Sleep Health and Wellness (SHAW) program and incorporate mindfulness techniques to meet the needs of this...
This federal Project Grant award, R01AG087163, in the amount of $780,466.00, was provided by the National Institute on Aging under the Aging Research program (CFDA 93.866). The grant aims to develop digital biomarkers using single-channel sleep electroencephalography (EEG) to monitor brain health and detect preclinical neurodegeneration, with a focus on Alzheimer's disease. The research team, led by the University of Colorado-Denver, will utilize over 15,000 sleep recordings from existing...
This $1,201,659 federal Project Grant award from the National Center for Complementary and Integrative Health (NCCIH) under the Research and Training in Complementary and Integrative Health program (CFDA 93.213) will support research on the mechanisms and consequences of infraslow oscillations in sleep. The award, with a period of performance from September 15, 2024 to May 31, 2029, will be led by the University of Pennsylvania with sub-awards to the University of Michigan and Colorado School of...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to investigate the bidirectional relationship between the spread of pathological protein aggregates, sleep, and circadian clock disruption in neurodegenerative diseases. The $2,181,132 award to Colorado State University, with a sub-award to the University of Massachusetts Amherst, will fund research to determine if neurodegenerative disease drives circadian and sleep disruption, if environmental...
This $690,763 federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will fund research to optimize responsive neurostimulation (RNS) therapy for treating epilepsy. The key objectives are to: 1) identify patient-specific white matter connectivity and stimulation field models that predict positive RNS outcomes, 2) investigate whether...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $684,924 to Northwestern University to conduct research on the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia. The project aims to systematically characterize central and peripheral measures of the NA system and assess their association with sleep quality and cognitive performance in older adults with insomnia, as well as...
This $446,875 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research to investigate whether genetic risk variants for Alzheimer's disease have a pleiotropic effect on sleep duration and other sleep phenotypes. The research will involve two complementary approaches: 1) in silico bioinformatic analysis to identify potential shared genetic factors between Alzheimer's disease and sleep traits, and 2) functional studies in zebrafish to directly...