Project Grant R01AG089369
- Federal Project Grant Award Summary The Johns Hopkins University received a $465,035 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded February 1, 2026, with completion targeted for January 31, 2031. This award supports the development and clinical validation of a novel non-contrast magnetic resonance imaging (MRI) technique termed Venous Transit Time Imaging by Changes in T1 Relaxation (VICTR) to measure venous transit time (VTT) in the...
- This Project Grant award of $437,875 from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund a 2-year research project at the University of California, San Diego to quantify neurovascular protein lifetimes in the central nervous system under healthy, aging, and Alzheimer's disease conditions. The key objectives are to generate a comprehensive atlas of neurovascular protein lifetimes and identify changes associated with aging and Alzheimer's disease. The project will...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded University of Wisconsin-Madison a $640,906 Project Grant effective June 1, 2025, through March 31, 2030, under the Aging Research program (CFDA 93.866). The project delivers advanced neuroimaging research and analysis services focused on elucidating cerebrovascular disease (CVD) pathways to cognitive decline. The primary products include the development and application of a suite of non-invasive vascular neuroimaging tools...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke (NINDS) awarded the University of Maryland, Baltimore a $427,625 Project Grant on July 17, 2025, under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. This award, with completion targeted for June 30, 2027, funds research to develop a toolbox for studying proteome plasticity in brain endothelial cells. The project addresses the critical mechanisms...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded The Johns Hopkins University a Project Grant of $618,410 under the Aging Research program (CFDA 93.866) for the period February 1, 2026 through January 31, 2029. The award funds the development of a deep learning-based miniature microscope designed to advance early detection and understanding of Alzheimer's disease (AD) pathology in preclinical models. The research addresses critical limitations in existing imaging...
- The National Institute on Aging awarded a $4.6 million Project Grant to Cornell University under the Aging Research program (CFDA 93.866) to develop new imaging techniques for measuring microvascular blood flow in Alzheimer's disease and related dementia models. The award will support the design of an adaptive excitation source for 2-photon and 3-photon fluorescence microscopy to simultaneously measure blood flow speeds in approximately 300 cortical or 50 deep white matter microvessels. This...
- Federal Grant Award Summary The National Institute on Aging awarded Vasoptic Medical, Inc. a $500,000 Project Grant under the Aging Research program (CFDA 93.866) on September 20, 2025, to develop VasoVue NV, an innovative imaging platform for early detection of Alzheimer's disease through noninvasive assessment of neurovascular reactivity. During Phase I (completion date September 19, 2026), the company will establish proof of concept using animal models by stimulating the mouse retina with...
- Summary New York University School of Medicine received a $3.1 million Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 15, 2025 through May 31, 2030. The award supports a multidisciplinary research initiative examining the relationship between peripheral immune dysfunction and vascular contributions to cognitive decline and dementia. The research integrates biofluid biomarkers—specifically platelet aggregation,...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received $1,469,914 in project grant funding from the National Institute on Aging under the Aging Research program (CFDA 93.866) for the period January 1, 2026 through December 31, 2030. The award supports research titled "Probing Mechanistic Links Between Endothelial Aging and Dementia," which develops and applies a novel human induced pluripotent stem cell-endothelial cell (hiPSC-EC) model to investigate the...
- Federal Project Grant Award Summary The Johns Hopkins University received a $1.6 million project grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective June 1, 2025 through February 28, 2030. The award supports research investigating the dysfunction of brain microvascular and lymphatic vessels in obesity-linked cognitive impairment. The research aims to develop non-invasive biomarkers for early diagnosis and treatment evaluation of cognitive...
Grant Summary The National Institute on Aging awarded a $589,154 Project Grant to the University of Maryland, Baltimore, effective February 1, 2026, through January 31, 2031, under the Aging Research program (CFDA 93.866). This award funds the development and validation of a normalized cerebrovascular reactivity (NCVR) magnetic resonance imaging technique to improve detection of vascular contributions to cognitive impairment in patients with small-vessel disease. The research will produce an advanced neuroimaging biomarker that normalizes blood oxygen level-dependent (BOLD) signal reactivity to CO2 challenges using hyperoxia challenges, thereby eliminating confounding physiological factors present in traditional CVR measurement approaches. This normalized approach is expected to provide direct quantification of cerebral blood flow changes and superior sensitivity for detecting CVR alterations compared to existing techniques. The project will deliver three primary research outputs: (1) development and validation of the NCVR technique with assessment of test-retest reproducibility and sensitivity to CVR changes; (2) validation of the NCVR method using averaged physiological data; and (3) refinement and clinical application of the technique for detecting vascular pathology in cognitive impairment populations. The research directly supports the National Institute on Aging's mission to advance understanding of aging-related diseases, particularly Alzheimer's disease and related dementias, by contributing a validated biomarker for use in longitudinal studies such as the MARKVCID study across 16 U.S. sites.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $589.2k | 1/20/26 |