Project Grant R01AG089354
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $670,904 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective February 15, 2026 through November 30, 2030. This award funds the longitudinal continuation of a cohort study examining aging-in-place and long-term care decision-making among older adults with Alzheimer's dementia. The research builds upon an existing cohort of 293...
- Federal Project Grant Award Summary Northwestern University's Sponsored Research Division received a $148,050 Project Grant from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded September 27, 2025, with completion targeted for May 31, 2028. The award supports scientific investigation into sex-specific hypothalamic pathology and immune infiltration in Alzheimer's disease (AD), addressing the critical knowledge gap regarding why nearly two-thirds of AD...
- Federal Project Grant Award Summary The Washington University, through its Office of Sponsored Research Services, received a $125,000 Project Grant from the National Institute on Aging (Aging Research program, CFDA 93.866) awarded on September 15, 2025, with a completion date of June 30, 2027. The award funds research investigating epigenetic modulations by sleep to mitigate neurodegeneration, specifically examining the mechanistic relationship between sleep loss and tau protein aggregation in...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded a $619,099 Project Grant to the University of California, Irvine under the Aging Research program (CFDA 93.866) effective February 1, 2026 through January 31, 2031. This five-year research initiative addresses a critical knowledge gap by investigating longitudinal relationships between Alzheimer's Disease (AD) pathophysiology, local sleep expression, and sleep-dependent memory across preclinical disease stages. The...
- Federal Project Grant Award Summary Washington State University received a $420,750 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective August 5, 2025 through July 31, 2027. The award funds a comprehensive research investigation examining the reciprocal interactions between cognitive performance, beta-amyloid (Aβ) aggregation, transcriptional processing, and sleep disruption in an Alzheimer's disease model. The research employs...
- Federal Project Grant Award Summary The National Institute on Aging (NIA) awarded The Washington University $578,856 on February 15, 2026, under the Aging Research program (CFDA 93.866) to conduct a five-year investigation into the relationship between sleep and neurodegenerative disease. The research project, titled "Sleep Reinforces Homeostatic Set-Points in Neural Activity and Mitigates Neurodegenerative Disease," will deliver scientific findings and methodological advances in...
- Federal Grant Award Summary Northwestern University's Sponsored Research Division received a $160,000 Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), effective September 30, 2025, with completion targeted for August 31, 2027. The award supports scientific research investigating the role of depolarizing gamma-aminobutyric acid (GABA) in Alzheimer's disease (AD) pathogenesis, with particular focus on understanding how alterations in...
- Federal Project Grant Award Summary The University of Michigan's Regents received a $107,097 Project Grant from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), awarded September 16, 2025, with completion targeted for June 30, 2027. The award funds research investigating the relationship between sleep disturbances and memory loss in aging populations, addressing a significant public health concern affecting older adults' independence and quality of life....
- Federal Project Grant Award Summary Northwestern University's Sponsored Research Division received a $640,000 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866), effective September 1, 2025, through August 31, 2027. The award funds the Study to Understand Participant Perspectives on Respite Uptake (SUPPORT), a qualitative research initiative designed to identify barriers and facilitators to Adult Day Services (ADS) utilization among family...
- Federal Grant Award Summary The National Institute on Aging (NIA) awarded UC San Diego a Project Grant totaling $182,173.00 (awarded March 1, 2026, with completion targeted for February 28, 2031) under the Aging Research program (CFDA 93.866). This research grant supports scientific investigation into the noradrenergic modulation of sleep and its relationship to memory consolidation. The primary deliverables include the development of computational models examining how the locus coeruleus—a...
Northwestern University's Sponsored Research Division received $691,009 in project grant funding from the National Institute on Aging under the Aging Research program (CFDA 93.866), awarded March 15, 2026, with a completion date of February 28, 2031. This research project investigates the proteomic signature of sleep and its implications for Alzheimer's disease by examining the relationship between sleep architecture, circulating protein biomarkers, and cognitive decline in older adults. The research deliverables include: (1) analysis of polysomnographic sleep biomarkers and proteomic blood biomarkers in a large longitudinal sample to identify molecular associations with neurocognitive function; (2) experimental human studies designed to isolate proteins modulated exclusively by sleep and their relationship to cognitive performance; and (3) development of a knowledge graph mapping inter-individual variation in circulating proteins, sleep endophenotypes, and cognitive changes before and after sleep. The project addresses a critical gap in understanding Alzheimer's disease mechanisms by establishing a network connecting neurocognitive dimensions, sleep endophenotypes, and molecular markers. The underlying hypothesis posits that specific biomolecules associated with neuronal pathways modulate the relationship between sleep disruption and cognitive decline, with potential implications for identifying novel intervention targets. This research aligns with the National Institute on Aging's mission to support investigations into prevention and treatment approaches for Alzheimer's disease and related dementias through biomedical and behavioral research.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $691.0k | 3/3/26 |