Project Grant R01AG088241
- This federal Project Grant award of $3,355,744 from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will fund a longitudinal study on the intergenerational impact of trauma exposure from the 9/11 attacks. The study aims to conduct a 4th wave of data collection on a cohort of 9/11-exposed parents and their indirectly exposed children to understand the long-term mental, physical, and cognitive effects of disaster experiences, as well as the role of aging on...
- This Project Grant award of $3,304,237 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a 40-year longitudinal study examining the links between early life adversity, cumulative life stress, and cellular aging in midlife women and their offspring. The study aims to assess which aspects of life course stress, including childhood, midlife, and cumulative stress, are associated with accelerated cellular aging at age 50. The study will repeat assessments of cell aging...
- This $200,310 project grant from the Department of Health and Human Services' National Institutes of Health National Institute on Aging will fund research into the differential impact of adverse childhood experiences and aging on brain health. Specifically, the Oklahoma State University grant will pursue two aims: 1) characterize cognitive performance across emerging and older adult cohorts stratified by ACEs, and 2) characterize brain-derived neurotrophic factor levels across the two age...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), will support research examining the impact of stressful and traumatic experiences on the well-being of unpaid family caregivers of individuals living with Alzheimer's disease and related dementias. The $774,120 award to Wake Forest University Health Sciences will fund a 5-year study to investigate how exposure to potentially traumatic events, both prior to and during...
- This federal Project Grant award of $240,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Vanderbilt University will be used to explore the effects of lifestyle on immune system activity and molecular markers of aging across populations with diverse lifestyles, from traditional subsistence-level to highly urban. The research will focus on analyzing three age-associated molecular phenotypes - gene expression, DNA methylation, and telomere length - in peripheral blood...
- This Project Grant award of $106,464 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at Brandeis University to investigate the associations among monoamine neurotransmitters, tau pathology, and emotional memory in aging. The research aims to use PET imaging techniques to directly measure monoamine synthesis capacity in the locus coeruleus and dorsal raphe nucleus, regions vulnerable to early tau pathology in Alzheimer's disease. The project will explore...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will provide $3,132,978 to Northwestern University to conduct a secondary analysis of data from multiple long-term observational studies on aging. The goal is to investigate the relationships between personality traits, interpersonal stress, cognitive aging, and the risk of Alzheimer's disease and related dementias (ADRD). The research will examine how changes in personality and...
- This Project Grant award of $1,851,569 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research investigating the relationship between early brain development and later neurodegeneration associated with Alzheimer's disease (AD). The research aims to test two key hypotheses: 1) brain regions with high plasticity in early life are more susceptible to pathological changes later in life, and 2) the detrimental impact of social determinants of health (e.g., low...
- This federal Project Grant award for $142,607, provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of North Carolina at Chapel Hill, will support research titled "Tracking Brain Structural Trajectories for Early Detection and Prognosis of Alzheimer's Disease." The project, led by Dr. Tengfei Li, aims to develop a comprehensive set of life-span brain structural reference standards and an explainable artificial intelligence system to facilitate...
- This Project Grant award of $189,199 from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a cross-sectional study investigating the neurodevelopmental effects of genetic risk for Alzheimer's disease in a cohort of periadolescent children aged 8-13 years old. The study aims to examine the relationships between cognition, physical activity, cardiorespiratory fitness, genetics, and the development of Alzheimer's disease-vulnerable brain networks. The project will collect...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $675,157 to the University of North Carolina at Chapel Hill (UNC-CH) to determine how molecular aging markers measured after psychological trauma predict and co-occur with persistent neuropsychiatric sequelae and age-related brain alterations. The central hypothesis is that advanced molecular age contributes to high risk for neuropsychiatric outcomes and concomitant age-related brain changes following trauma. The research aims to 1) assess how integrative molecular aging markers at the time of trauma predict neuropsychiatric outcomes, 2) uncover the temporal dynamics of molecular age along these outcome trajectories, and 3) define the functional and structural brain changes associated with molecular age after trauma. This award leverages established multi-ancestry cohorts and will provide novel predictors and insights to guide interventions promoting brain health and alleviating neuropsychiatric effects across the age spectrum.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $675.2k | 8/18/25 |