This $2,085,904 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to investigate the role of glycated tau and advanced glycation end products (AGEs) in the pathology, neurotoxicity, aggregation, and neuroinflammation associated with Alzheimer's disease (AD). The 5-year project, commencing on May 1, 2024, will be conducted by the University of Colorado and aims to provide molecular-level insights into the connections between type 2 diabetes, hyperglycemia, and increased AD risk. Key research activities include in vitro studies on how specific tau proteoforms and other reactive dicarbonyl species contribute to AD progression, as well as evaluating the effects of glycation, AGE structures, and dopegalattachment on interneuronal transmission, inflammation, and mitochondrial dysfunction. The ultimate goal is to enable more precise AD diagnosis and inform the development of novel therapeutic approaches targeting non-enzymatic protein modifications.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $662.7k | 3/31/25 | ||
| Not listed | $711.6k | 4/29/24 | ||
| Not listed | $711.6k | 4/29/24 |