Project Grant R01AG087295

Award Date 5/1/24
Completion Date 4/30/29
Dollars Obligated $2.1M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Boulder, CO 80309, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $633,376 to Colorado State University to conduct research aimed at understanding how age-related declines in endosome formation contribute to the development of Alzheimer's disease (AD) and other protein-based neurodegenerative disorders. The key objectives are to: 1) Determine how increasing endosome formation can decrease pathological tau protein levels in neurons, and 2) Evaluate the impact...
This $326,797 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) aims to use proteomic analyses to identify proteins and protein networks associated with mild cognitive impairment in individuals with type 2 diabetes. The project's primary goal is to illuminate the underlying molecular mechanisms driving cognitive impairment in this population, with the potential to identify biomarkers for risk stratification and protein targets for therapeutic...
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This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), will investigate the synergistic relationship between the tau and TDP-43 proteins in the pathogenesis of Alzheimer's disease (AD). The $757,027 award, effective from January 1, 2025 to December 31, 2029, will utilize a C. elegans model to interrogate the mechanistic pathways underlying the interaction between tau and TDP-43 proteinopathies. The project aims to identify...
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