This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $5,262,301 to Trustees of Boston University, doing business as Boston University Medical Campus, to conduct the "Triangulation of Innovative Methods to End AD (TIME-AD)" research program. The project aims to strengthen causal inference in observational data on modifiable risk factors for Alzheimer's disease and related dementias, using innovative methods such as doubly robust observational analysis, instrumental variables, and quantitative bias analysis. The research will address the effects of alcohol use, depression, sensory impairments, and social isolation on cognitive aging and dementia risk across diverse populations. The award includes support for data management, genetic and policy analysis, advanced analytics, and equity-focused dissemination to improve outcomes for underrepresented groups. This multi-component program leverages Boston University's extensive expertise in neuroscience, biomedical engineering, and public health research to deliver high-impact findings that can guide prevention strategies for Alzheimer's disease.
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