This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will provide $2,239,532 to support research on the relationship between optimism and cognitive health outcomes, including Alzheimer's disease and related dementias. The project will leverage data from multiple large cohort studies to examine how optimism relates to long-term cognitive trajectories, daily cognitive function, physical activity, and the gut microbiome. Key activities include harmonizing cognitive test data across cohorts, deploying a mobile app to collect intensive cognitive and physical activity data, and conducting exploratory analyses on optimism and the gut microbiome. The project involves sub-awards to Brigham & Women's Hospital, Rush University Medical Center, and the University of California, Davis to contribute specialized expertise in epidemiological analysis, mobile health data collection, and cognitive data harmonization. Findings from this comprehensive, multi-year study are expected to provide new insights into psychological resilience factors that may help prevent or delay age-related cognitive decline.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $0 | 1/15/25 | ||
| Not listed | $1.1m | 8/29/24 | ||
| Not listed | $1.1m | 8/29/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
1150745129667S | Brigham & Womens Hospital Inc. | Project Grant R01AG085375 | $86.9k | 12/16/24 | |
1150745129663S | Rush University Medical Center | Project Grant R01AG085375 | $118.1k | 12/9/24 | |
1150745129669S | University Of Washington | Project Grant R01AG085375 | $172.7k | 12/6/24 | |
1150745129665S | University Of California, Davis | Project Grant R01AG085375 | $98.9k | 12/2/24 |