The National Institute on Aging (NIA) awarded a $622,401 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Southern California (USC) Department of Contracts and Grants Division. The 5-year grant, commencing on January 1, 2025, aims to develop sophisticated AI models and causal analysis techniques to elucidate the spatial and temporal patterns of brain biomarker changes associated with Alzheimer's disease and related dementias (ADRD).
Specifically,...
This Project Grant award, valued at $332,135.00, was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The purpose of the award is to investigate the relationship between early-life education availability/quality and Alzheimer's disease and related dementias (ADRD) risk, with a focus on potential racial disparities.
The study will leverage and expand an existing occupational cohort of GM autoworkers, linking this data to historical...
This $1,834,298 five-year Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a study to evaluate the causal effects of K-12 and college educational experiences on cognitive health and functioning in older adults. The study will leverage a natural experiment provided by the National Defense Education Act (NDEA) funding from 1958-1964 to improve science, technology, engineering, mathematics (STEM), and foreign language education in K-12 schools and...
The National Institute on Aging (NIA) awarded a $661,016 Project Grant (CFDA 93.866 - Aging Research) to the University of Southern California (USC) to launch the "Federate AD" alliance. This international initiative will develop a distributed artificial intelligence (AI) platform to enable researchers worldwide to collaboratively analyze Alzheimer's disease (AD) data and discover factors influencing disease onset and progression. The project will: (1) diagnose and subtype dementia...
The National Institute on Aging (NIA) awarded a $4,444,978 Project Grant under the Aging Research (CFDA 93.866) federal grant program to the Regents of the University of Michigan to conduct research on later-life cognitive reserve and resilience among older adults with and without formal education in India. The primary goals are to 1) compare the contributions of brain pathology measures to cognition between older adults with and without formal education, 2) evaluate the roles of employment,...
The University of Southern California (USC) was awarded a $826,222 Project Grant from the National Institute on Aging's Aging Research program (CFDA 93.866) to study the role of the cGAS-STING innate immune pathway in neuroinflammation and Alzheimer's disease pathogenesis. The key objectives are to: 1) investigate how cGAS-STING modulates neuroinflammation in cellular models and animal studies; 2) assess the impact of herpes simplex virus (HSV-1) infection on the cGAS-STING pathway and...
This federal Project Grant award for $798,110, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), will leverage data from the Interplay of Genes and Environments across Studies (IGEMS) Consortium to clarify modifiable risk factors for Alzheimer's disease and related dementias across the lifespan. The project aims to: (1) evaluate mid-life and late-life physical health and behavioral factors that alter dementia risk; (2) assess socioemotional...
This National Institute on Aging (NIA) Project Grant award (CFDA 93.866 Aging Research) provides $1,277,367 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the early detection and prevention of Alzheimer's disease and related dementias (ADRD) among Black and White adults in their 60s. The project aims to:
Investigate the midlife to early late-life transition to clinical ADRD, including the role of neurodegenerative and vascular pathways, as well as...
This National Institutes of Health National Institute on Aging project grant award of $860,772 to Bowling Green State University will fund research and training from June 2022 through May 2025 under the Aging Research program (CFDA 93.866). The university will evaluate the relationship between adult children's education levels and parental risk of Alzheimer's disease and related dementias using Health and Retirement Study panel data. Researchers will compare conceptualizations of offspring...
The University of Southern California (USC) was awarded a $14,830,578 Cooperative Agreement by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to establish the Gateway Exposome Coordinating Center (GECC) for Alzheimer's Disease and Alzheimer's-Related Dementias (AD/ADRD) research. The GECC will bring together experts and stakeholders to identify exposome research priorities, develop harmonized exposome measures, and provide guidance for using...
The National Institute on Aging (NIA) awarded a $3,699,536 Project Grant under the Aging Research federal grant program (CFDA 93.866) to the University of Southern California (USC) to investigate the relationship between education and Alzheimer's disease and related dementias (ADRD). The grant will leverage the International Geroscience Environment and Mild Traumatic Brain Injury Study (IGEMS) consortium of longitudinal twin studies to examine how country, birth cohort, and gender disparities in access to education and occupation impact cognitive outcomes including ADRD. USC will collaborate with sub-awardees Karolinska Institutet, University of Colorado, and University of Southern Denmark to integrate genetic, individual, intergenerational, and environmental measures of education and analyze their effects. The project aims to elucidate mechanisms underlying the protective role of education against ADRD, accounting for demographic and social inequalities. Work under this 5-year award will commence on May 15, 2024.