Longitudinal examination of neighborhood disadvantage, cognitive aging, and alzheimer's disease risk in disinvested, african american neighborhoods

Ended Project Grant Awarded Last action

Award ID
R01AG072652
Recipient
Awarding agency
Obligated
$30,007,233

Award facts

Assistance listing
93.866 Aging Research
Completion date
Place of performance
Pittsburgh, PA 15222, USA

Award details come from USAspending.gov.

Description

As the agency reported it.

Abstract
African americans (AAS) have disproportionately higher rates and earlier onset of alzheimer's disease and related dementias (adrd) relative to white americans. Although prior research has made significant contributions to our understanding of racial disparities in adrd, we still lack a comprehensive understanding of how the individual lived experience of being AA, including cumulative exposure to structural racism, contributes to elevated adrd risk and the potential mechanisms underlying those risks. Building on the existing, community-based research infrastructure developed by our team's previously funded studies, we will follow a cohort of residents (n=1133) living in two historically disinvested, predominantly AA communities to understand how dynamic neighborhood socioeconomic conditions across the lifecourse contribute to cognitive outcomes in mid- and late-life adults. This proposal rests on the premise that neighborhood segregation and subsequent disinvestment contributes to poor cognitive outcomes for AAS via factors including a) lower access to educational opportunities and b) higher exposure to race- and socioeconomically-relevant stressors, including discrimination, trauma, and adverse childhood events. In turn, these cumulative exposures foster psychological vigilance in residents, leading to cardiometabolic dysregulation and sleep disruption, which may mediate associations between neighborhood disadvantage and adrd risk. We also will examine potential protective factors that may promote cognitive health, including neighborhood social cohesion, safety, and satisfaction. The proposed study will leverage our existing longitudinal data on risk and protective factors, biobehavioral mediators, and baseline cognitive assessments, and will include: 1) three waves of cognitive assessments in the full cohort of participants who are 50 years+ (participants who are aged 35-49 years will have two assessments) and clinical adjudication of adrd in participants who are 50+ (n=906), 2) additional assessments of blood pressure and objective sleep, 3) a comprehensive assessment of life and residential history using the questionnaire from the health and retirement study (HRS); and 4) in-depth qualitative interviews to reveal lifecourse opportunities and barriers experienced by AAS in achieving optimal cognitive health in late life. Understanding how structural racism has influenced the lived experience of AAS including dynamic changes in neighborhood conditions over time is critical to inform multi-level intervention and policy efforts to reduce pervasive racial and socioeconomic disparities in adrd.

Transactions

Action Obligated Date
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Original award $2,267,650
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Subawards

Subrecipient Amount Awarded
The Rand Corporation Longitudinal Examination of Neighborhood Disadvantage, Cognitive Aging, and Alzheimer's Disease Risk in Disinvested, African American Neighborhoods $715,982
The Rand Corporation $456,040
The Regents Of The University Of California. San Francisco $57,867
The Regents Of The University Of California. San Francisco $64,298
University Of Pittsburgh - Of The Commonwealth System Of Higher Education $78,352
University Of Pittsburgh - Of The Commonwealth System Of Higher Education $707,431
University Of Pittsburgh - Of The Commonwealth System Of Higher Education $1,917,535

Quick answers

Who received award R01AG072652?

R01AG072652 was awarded to University Of Pittsburgh - Of The Commonwealth System Of Higher Education by National Institute on Aging (National Institutes of Health) on February 15, 2022.

How much is award R01AG072652 worth?

$30,007,233 has been obligated on R01AG072652.

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